CAS Number382-44-5
SynonymsU 2826; 11β-hydroxyandrost-4-ene-3,17-dione; (11β)-11-Hydroxyandrost-4-ene-3,17-dione; 4-Androsten-11beta-ol-3,17-dione; 11beta-Hydroxyandrostenedione; 11β-Hydroxy-4-androsten-3,17-dione; 11beta-Hydroxyandrost-4-ene-3,17-dione; Androst-4-ene-3,17-dione-11beta-ol; 11b-Hydroxyandrost-4-ene-3,17-dione
Molecular FormulaC19H26O3
Molecular Weight302.408
Density1.2±0.1 g/cm3
Boiling Point475.3±45.0 °C at 760 mmHg
Melting Point197-199℃
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 382-44-5 |
| Catalog No. | 2A-9079754 |
| Chinese Name | 4-雄烯-11β-醇-3,17-二酮 |
| Synonyms | U 2826; 11β-hydroxyandrost-4-ene-3,17-dione; (11β)-11-Hydroxyandrost-4-ene-3,17-dione; 4-Androsten-11beta-ol-3,17-dione; 11beta-Hydroxyandrostenedione; 11β-Hydroxy-4-androsten-3,17-dione; 11beta-Hydroxyandrost-4-ene-3,17-dione; Androst-4-ene-3,17-dione-11beta-ol; 11b-Hydroxyandrost-4-ene-3,17-dione |
| Molecular Formula | C19H26O3 |
| Molecular Weight | 302.408 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 475.3±45.0 °C at 760 mmHg |
| Melting Point | 197-199℃ |
| Storage Condition | room temperature |
| Application | 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid found primarily in the adrenal glands (11β-hydroxylase is present in adrenal tissue but not in ovarian tissue). 11-Beta-hydr |
| PubChem ID | 7671 |
| SMILES | CC12CC(O)C3C(CCC4=CC(=O)CCC43C)C1CCC2=O |
| InChI | InChI=1S/C19H26O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-15,17,21H,3-8,10H2,1-2H3/t13-,14-,15-,17+,18-,19-/m0/s1 |
| InChI Key | WSCUHXPGYUMQEX-KCZNZURUSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/79754_1_382_44_5.pdf |
| Bioactivity | 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2]. Related Catalog Research Areas >> Endocrinology Target Human Endogenous Metabolite In Vitro In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively[2]. In Vivo The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism[1]. References [1]. Ibrahim F, et al. Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer. J Steroid Biochem Mol Biol. 2003 Apr;84(5):563-8. [2]. Rachelle Gent, et al. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17αhydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 475.3±45.0 °C at 760 mmHg Melting Point 197-199℃ Molecular Formula C19H26O3 Molecular Weight 302.408 Flash Point 255.4±25.2 °C Exact Mass 302.188202 PSA 54.37000 LogP 1.27 Vapour Pressure 0.0±2.7 mmHg at 25°C Index of Refraction 1.569 InChIKey WSCUHXPGYUMQEX-KCZNZURUSA-N SMILES CC12CC(O)C3C(CCC4=CC(=O)CCC43C)C1CCC2=O |
| Use of | 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2]. Properties Articles27 Name 11β-hydroxyandrost-4-ene-3,17-dione Synonym More Synonyms 11-Beta-hydroxyandrostenedione Biological Activity Description 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2]. Related Catalog Research Areas >> Endocrinology Human Endogenous Metabolite In Vitro In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively[2]. In Vivo The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism[1]. References [1]. Ibrahim F, et al. Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer. J Steroid Biochem Mol Biol. 2003 Apr;84(5):563-8. [2]. Rachelle Gent, et al. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17αhydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol Chemical & Physical Properties Molecular Formula C19H26O3 Exact Mass 302.188202 PSA 54.37000 Index of Refraction 1.569 InChIKey WSCUHXPGYUMQEX-KCZNZURUSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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