CAS Number35661-60-0
SynonymsD-LeuFmoc-OH; Fmoc-Leu-OH; N-((9H-Fluoren-9-ylmethoxy)carbonyl)-L-leucine; EINECS 252-662-7; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid; MFCD00037133; Tocris-0675; FMOC-D-LEU; Fmoc-D-Leu-OH; Fmoc-L-leucine; Fmoc-L-Leu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucine; Fmoc-D-leucine-OH; N-Fmoc-D-leucine; D-Fmoc-Leu-OH; N-Fmoc-L-leucine; Fmoc-D-Leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine
Molecular FormulaC21H23NO4
Molecular Weight353.41
Purity≥97.0%
Density1.2±0.1 g/cm3
Boiling Point559.8±33.0 °C at 760 mmHg
Melting Point152-156 °C
AppearanceWhite crystalline powder
EINECS252-662-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 35661-60-0 |
| Catalog No. | 2A-9007852 |
| Chinese Name | Fmoc-L-亮氨酸 |
| Synonyms | D-LeuFmoc-OH; Fmoc-Leu-OH; N-((9H-Fluoren-9-ylmethoxy)carbonyl)-L-leucine; EINECS 252-662-7; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid; MFCD00037133; Tocris-0675; FMOC-D-LEU; Fmoc-D-Leu-OH; Fmoc-L-leucine; Fmoc-L-Leu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucine; Fmoc-D-leucine-OH; N-Fmoc-D-leucine; D-Fmoc-Leu-OH; N-Fmoc-L-leucine; Fmoc-D-Leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine |
| Molecular Formula | C21H23NO4 |
| Molecular Weight | 353.41 |
| Purity | ≥97.0 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 559.8±33.0 °C at 760 mmHg |
| Melting Point | 152-156 °C |
| Appearance | White crystalline powder |
| Storage Condition | Sealed, cool and dry storage |
| Application | Fmoc leucine is a selective PPARγ modulator. The potency of Fmoc leucine to activate PPARγ is lower but similar to that of rosiglitazone. Fmoc leucine improves insulin sensitivity in normal, diet-indu |
| EINECS | 252-662-7 |
| HTC | 2924299090 |
| PubChem ID | 57651051 |
| MDL Number | MFCD00037133 |
| SMILES | CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O |
| InChI | 1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1 |
| InChI Key | CBPJQFCAFFNICX-IBGZPJMESA-N |
| Beilstein/REAXYS | 2178254 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/7852_1_35661_60_0.pdf |
| Bioactivity | Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease Target PPARγ References [1]. Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 559.8±33.0 °C at 760 mmHg Melting Point 152-156 °C(lit.) Molecular Formula C21H23NO4 Molecular Weight 353.412 Flash Point 292.4±25.4 °C Exact Mass 353.162720 PSA 75.63000 LogP 4.95 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.583 InChIKey CBPJQFCAFFNICX-IBGZPJMESA-N SMILES CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O Storage condition 2~8°C |
| Use of | Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1]. Properties Name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid Synonym More Synonyms Fmoc-Leu-OH Biological Activity Description Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease References [1]. Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47. Chemical & Physical Properties Molecular Formula C21H23NO4 Exact Mass 353.162720 PSA 75.63000 Index of Refraction 1.583 InChIKey CBPJQFCAFFNICX-IBGZPJMESA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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