CAS Number109425-51-6
SynonymsMFCD00043332; N-Fmoc-N'-Trityl-L-Histidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine; N-alpha-FMOC-N-Trityl-L-histidine; EINECS 439-640-4; Nα-Fmoc-N(im)-trityl-L-histidine; Na-Fmoc-Nim-trityl-L-histidine; Fmoc-His(Trt)-OH; Nα-[(9H-Fluoren-9-ylMethoxy)carbonyl]-tele-(triphenylMethyl)-L-histidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine,; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid; Nα-Fmoc-τ-trityl-L-histidine; Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine
Molecular FormulaC40H33N3O4
Molecular Weight619.71
Purity≥98.0 (sum of enantiomers, HPLC)%
Density1.2±0.1 g/cm3
Boiling Point811.7±65.0 °C at 760 mmHg
Melting Point150-155 °C(lit.)
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 109425-51-6 |
| Catalog No. | 2A-0201753 |
| Chinese Name | N-Fmoc-N'-三苯甲基-L-组氨酸 |
| Synonyms | MFCD00043332; N-Fmoc-N'-Trityl-L-Histidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine; N-alpha-FMOC-N-Trityl-L-histidine; EINECS 439-640-4; Nα-Fmoc-N(im)-trityl-L-histidine; Na-Fmoc-Nim-trityl-L-histidine; Fmoc-His(Trt)-OH; Nα-[(9H-Fluoren-9-ylMethoxy)carbonyl]-tele-(triphenylMethyl)-L-histidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine,; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid; Nα-Fmoc-τ-trityl-L-histidine; Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine |
| Molecular Formula | C40H33N3O4 |
| Molecular Weight | 619.71 |
| Purity | ≥98.0 (sum of enantiomers, HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 811.7±65.0 °C at 760 mmHg |
| Melting Point | 150-155 °C(lit.) |
| Appearance | White crystalline powder |
| Water Solubility | Soluble in: dimethylformamide |
| Storage Condition | Store airtight in a cool, dry warehouse. Refrigera |
| Application | Fmoc-His(Trt)-OH has a triphenyl (Trt) group to protect the side chain of His. Fmoc-His(Trt)-OH has an Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used in solid-phase synthesis of peptides, p |
| PubChem ID | 57651056 |
| MDL Number | MFCD00043332 |
| SMILES | OC(=O)[C@H](Cc1cn(cn1)C(c2ccccc2)(c3ccccc3)c4ccccc4)NC(=O)OCC5c6ccccc6-c7ccccc57 |
| InChI | 1S/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-43(27-41-31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/t37-/m0/s1 |
| InChI Key | XXMYDXUIZKNHDT-QNGWXLTQSA-N |
| Beilstein/REAXYS | 5204720 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| Bioactivity | Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 811.7±65.0 °C at 760 mmHg Melting Point 150-155 °C(lit.) Molecular Formula C40H33N3O4 Molecular Weight 619.708 Flash Point 444.7±34.3 °C Exact Mass 619.247131 PSA 93.45000 LogP 8.03 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.657 InChIKey XXMYDXUIZKNHDT-QNGWXLTQSA-N SMILES O=C(NC(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)C(=O)O)OCC1c2ccccc2-c2ccccc21 Storage condition 2-8°C |
| Use of | Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1]. Properties Name N-Fmoc-N'-trityl-L-histidine Synonym More Synonyms Fmoc-His(Trt)-OH Biological Activity Description Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27. Chemical & Physical Properties Molecular Formula C40H33N3O4 Exact Mass 619.247131 PSA 93.45000 Index of Refraction 1.657 InChIKey XXMYDXUIZKNHDT-QNGWXLTQSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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