![[2-[2-(Fmoc-Amino)ethoxy]ethoxy]aceticacid structure, CAS 166108-71-0](/structures/80000/77894_1_166108_71_0.png)
CAS Number166108-71-0
Synonyms[2-[2-(Fmoc-Amino)ethoxy]ethoxy]acetic acid; [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid; 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid; {2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-acetic acid; MFCD01321015; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid; [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid; 2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid; 8-[(9H-Fluoren-9-ylMethoxy)carbonylaMino]-3,6-dioxa-n-octanoic Acid; Fmoc-mini-PEG; Fmoc-AEEA
Molecular FormulaC21H23NO6
Molecular Weight385.41
Purity≥95.0 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point631.4±45.0 °C at 760 mmHg
Melting Point90-92℃
Appearancepowder
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 166108-71-0 |
| Catalog No. | 2A-9077894 |
| Chinese Name | [2-[2-(Fmoc-氨基)乙氧基]乙氧基]乙酸 |
| Synonyms | [2-[2-(Fmoc-Amino)ethoxy]ethoxy]acetic acid; [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid; 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid; {2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-acetic acid; MFCD01321015; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid; [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid; 2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid; 8-[(9H-Fluoren-9-ylMethoxy)carbonylaMino]-3,6-dioxa-n-octanoic Acid; Fmoc-mini-PEG; Fmoc-AEEA |
| Molecular Formula | C21H23NO6 |
| Molecular Weight | 385.41 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 631.4±45.0 °C at 760 mmHg |
| Melting Point | 90-92℃ |
| Appearance | powder |
| Storage Condition | -15°C |
| Application | Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. |
| HTC | 2934999090 |
| PubChem ID | 329770411 |
| MDL Number | MFCD01321015 |
| SMILES | OC(=O)COCCOCCNC(=O)OCC1c2ccccc2-c3ccccc13 |
| InChI | 1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24) |
| InChI Key | XQPYRJIMPDBGRW-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/77894_1_166108_71_0.pdf |
| Bioactivity | Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 631.4±45.0 °C at 760 mmHg Melting Point 90-92℃ Molecular Formula C21H23NO6 Molecular Weight 385.410 Flash Point 335.6±28.7 °C Exact Mass 385.152527 PSA 94.09000 LogP 2.63 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.580 InChIKey XQPYRJIMPDBGRW-UHFFFAOYSA-N SMILES O=C(O)COCCOCCNC(=O)OCC1c2ccccc2-c2ccccc21 Storage condition -15°C |
| Use of | Properties Name [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Synonym More Synonyms Fmoc-8-amino-3,6-dioxaoctanoic acid Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211. Chemical & Physical Properties Molecular Formula C21H23NO6 Exact Mass 385.152527 PSA 94.09000 Index of Refraction 1.580 InChIKey XQPYRJIMPDBGRW-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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