CAS Number193693-64-0
Synonyms1-Fmoc-Azetidine-3-carboxylic acid; 1,3-Azetidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-Azetidine-3-carboxylic acid; MFCD01321018; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]azetidine-3-carboxylic acid; Fmoc-L-Azetidine-3-carboxylicacid; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid
Molecular FormulaC19H17NO4
Molecular Weight323.343
Density1.4±0.1 g/cm3
Boiling Point543.3±43.0 °C at 760 mmHg
Melting Point174 °C
AppearanceLight yellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 193693-64-0 |
| Catalog No. | 2A-9077751 |
| Chinese Name | Fmoc-L-3-吖丁啶羧酸 |
| Synonyms | 1-Fmoc-Azetidine-3-carboxylic acid; 1,3-Azetidinedicarboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-Azetidine-3-carboxylic acid; MFCD01321018; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]azetidine-3-carboxylic acid; Fmoc-L-Azetidine-3-carboxylicacid; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid |
| Molecular Formula | C19H17NO4 |
| Molecular Weight | 323.343 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 543.3±43.0 °C at 760 mmHg |
| Melting Point | 174 °C |
| Appearance | Light yellow powder |
| Storage Condition | 2-8°C |
| Application | Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also an alkyl chain-based PROTAC linker and can be |
| HTC | 2933990090 |
| PubChem ID | 3182373 |
| SMILES | O=C(O)C1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1 |
| InChI | InChI=1S/C19H17NO4/c21-18(22)12-9-20(10-12)19(23)24-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17H,9-11H2,(H,21,22) |
| InChI Key | QDEJCUHGSHSYQH-UHFFFAOYSA-N |
| Bioactivity | Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 543.3±43.0 °C at 760 mmHg Melting Point 174 °C Molecular Formula C19H17NO4 Molecular Weight 323.343 Flash Point 282.3±28.2 °C Exact Mass 323.115753 PSA 66.84000 LogP 2.71 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.651 InChIKey QDEJCUHGSHSYQH-UHFFFAOYSA-N SMILES O=C(O)C1CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1 Storage condition 2-8°C |
| Use of | Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Properties Name 1-(9H-fluoren-9-ylmethoxycarbonyl)azetidine-3-carboxylic acid Synonym More Synonyms Fmoc-azetidine-3-carboxylic acid Biological Activity Description Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C19H17NO4 Exact Mass 323.115753 PSA 66.84000 Index of Refraction 1.651 InChIKey QDEJCUHGSHSYQH-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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