![2-Ethoxy-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionicacid structure, CAS 251565-85-2](/structures/80000/77558_1_251565_85_2.png)
CAS Number251565-85-2
Synonyms(2S)-2-Ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid; Galida; tesaglitazar; (S)-2-ethoxy-3-[4-(2-{4-methanesulfonyloxy-phenyl}ethoxy)phenyl]propanoic acid; AZ-242; (S)-2-Ethoxy-3-{4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl}propionic acid; (S)-2-ethoxy-3-[4-(2-{4-methanesulphonyloxyphenyl}ethoxy)phenyl]propanoic acid; (2S)-2-ethoxy-3-[4-(2-{4-[(methylsuIfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid; AZ2; (2S)-2-Ethoxy-3-[4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]phenyl]propanoic acid; (S)-2-ethoxy-3-(4-(2-(4-methylsulphonyloxyphenyl)ethoxy)phenyl)propanoic acid
Molecular FormulaC20H24O7S
Molecular Weight408.47
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point611.3±55.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 251565-85-2 |
| Catalog No. | 2A-9077558 |
| Chinese Name | 替格列扎 |
| Synonyms | (2S)-2-Ethoxy-3-[4-(2-{4-[(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid; Galida; tesaglitazar; (S)-2-ethoxy-3-[4-(2-{4-methanesulfonyloxy-phenyl}ethoxy)phenyl]propanoic acid; AZ-242; (S)-2-Ethoxy-3-{4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl}propionic acid; (S)-2-ethoxy-3-[4-(2-{4-methanesulphonyloxyphenyl}ethoxy)phenyl]propanoic acid; (2S)-2-ethoxy-3-[4-(2-{4-[(methylsuIfonyl)oxy]phenyl}ethoxy)phenyl]propanoic acid; AZ2; (2S)-2-Ethoxy-3-[4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]phenyl]propanoic acid; (S)-2-ethoxy-3-(4-(2-(4-methylsulphonyloxyphenyl)ethoxy)phenyl)propanoic acid |
| Molecular Formula | C20H24O7S |
| Molecular Weight | 408.47 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 611.3±55.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Tesaglitazar is a dual peroxisomal PPAR alpha/gamma receptor agonist with a stronger effect on PPARγ than PPARα, with an EC50 of 13.4 μM and 3.6 μM for rat and human PPARα, respectively, and an EC50 o |
| HTC | 2918990090 |
| PubChem ID | 329825823 |
| MDL Number | MFCD07784004 |
| SMILES | O=S(OC1=CC=C(CCOC2=CC=C(C[C@H](OCC)C(O)=O)C=C2)C=C1)(C)=O |
| InChI | 1S/C20H24O7S/c1-3-25-19(20(21)22)14-16-6-8-17(9-7-16)26-13-12-15-4-10-18(11-5-15)27-28(2,23)24/h4-11,19H,3,12-14H2,1-2H3,(H,21,22)/t19-/m0/s1 |
| InChI Key | CXGTZJYQWSUFET-IBGZPJMESA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/77558_1_251565_85_2.pdf |
| Use of | Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1]. Properties Name (2S)-2-ethoxy-3-[4-[2-(4-methylsulfonyloxyphenyl)ethoxy]phenyl]propanoic acid Synonym More Synonyms tesaglitazar Biological Activity Description Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease EC50: 13.4 μM (rat PPARα), 3.6 μM (human PPARα), 0.2 μM (PPARγ)[1] References [1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74. Chemical & Physical Properties Molecular Formula C20H24O7S Exact Mass 408.124268 PSA 107.51000 Index of Refraction 1.566 InChIKey CXGTZJYQWSUFET-IBGZPJMESA-N Safety Information Signal Word Warning Hazard Statements H302 Precautionary Statements P301 + P312 + P330 RIDADR NONH for all modes of transport HS Code 2918990090 Synthetic Route Total: 1 Page 1,4-Dioxane CAS#:123-91-1 (S)-2-ethoxy-N-... CAS#:251565-89-6 CAS#:142-82-5 tesaglitazar CAS#:251565-85-2 Literature: AstraZeneca AB Patent: US6258850 B1, 2001 ; ethyl (2S)-2-et... CAS#:251565-91-0 tesaglitazar CAS#:251565-85-2 Precursor & DownStream Precursor 4 CAS#:123-91-1 1,4-Dioxane CAS#:251565-89-6 (S)-2-ethoxy-N-... CAS#:142-82-5 CAS#:251565-91-0 ethyl (2S)-2-et... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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