CAS Number23243-68-7
Synonyms2,2'-(ethane-1,2-diylbis(oxy))diacetic acid; 3,6-dioxaoctadioic acid; 3,6-dioxoctanedioic acid; 3,6-dioxa-1,8-octanedioic acid; 3,6-dioxaoctane-1,8-dioic acid; 3,6-DIOXAOCTANEDIOIC ACID; (2-carboxymethoxyethoxy)acetic acid; 3,6-dioxaoctandioic acid
Molecular FormulaC6H10O6
Molecular Weight178.14
Density1.375g/cm3
Boiling Point429.2ºC at 760mmHg
Melting Point68-71℃
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 23243-68-7 |
| Catalog No. | 2A-9077170 |
| Chinese Name | 3,6-二氧苯贰酸 |
| Synonyms | 2,2'-(ethane-1,2-diylbis(oxy))diacetic acid; 3,6-dioxaoctadioic acid; 3,6-dioxoctanedioic acid; 3,6-dioxa-1,8-octanedioic acid; 3,6-dioxaoctane-1,8-dioic acid; 3,6-DIOXAOCTANEDIOIC ACID; (2-carboxymethoxyethoxy)acetic acid; 3,6-dioxaoctandioic acid |
| Molecular Formula | C6H10O6 |
| Molecular Weight | 178.14 |
| Density | 1.375g/cm3 |
| Boiling Point | 429.2ºC at 760mmHg |
| Melting Point | 68-71℃ |
| Storage Condition | Store below +30°C. |
| Packaging | III |
| Application | 36-Dioxaoctanedioic acid is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| HTC | 2918990090 |
| PubChem ID | 74468 |
| SMILES | O=C(O)COCCOCC(=O)O |
| InChI | InChI=1S/C6H10O6/c7-5(8)3-11-1-2-12-4-6(9)10/h1-4H2,(H,7,8)(H,9,10) |
| InChI Key | CQWXKASOCUAEOW-UHFFFAOYSA-N |
| Use of | 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 2-[2-(carboxymethoxy)ethoxy]acetic acid Synonym More Synonyms 3,6-Dioxaoctanedioic acid Biological Activity Description 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C6H10O6 Exact Mass 178.04800 PSA 93.06000 Index of Refraction 1.474 InChIKey CQWXKASOCUAEOW-UHFFFAOYSA-N SMILES O=C(O)COCCOCC(=O)O Safety Information Hazard Codes C: Corrosive; Risk Phrases R34 RIDADR UN 3261 Packaging Group III HS Code 2918990090 Synthetic Route Total: 1 Page Triethylene glycol CAS#:112-27-6 3,6-Dioxaoctane... CAS#:23243-68-7 Literature: Kuroboshi, Manabu; Yoshida, Tomonori; Oshitani, Jun; Goto, Kuniaki; Tanaka, Hideo Tetrahedron, 2009 , vol. 65, # 34 p. 7177 - 7185 2,2'-((Oxybis(e... CAS#:112-60-7 Diglycolic acid CAS#:110-99-6 3,6-Dioxaoctane... CAS#:23243-68-7 3,6,9-Trioxaund... CAS#:13887-98-4 Literature: Tetrahedron, , vol. 38, # 22 p. 3299 - 3308 Precursor & DownStream Precursor 2 CAS#:112-27-6 Triethylene glycol CAS#:112-60-7 2,2'-((Oxybis(e... DownStream 4 CAS#:31255-09-1 2-[2-(2-chloro-... CAS#:72469-41-1 2-[2-[2-(diocta... CAS#:73487-00-0 cadmium ionophore i CAS#:58774-46-2 2-[2-[2-(diprop... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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