CAS Number498-94-2
SynonymsIsonipecotic acid; 4-Hexahydroisonicotinic acid; Piperidine-4-carboxylic acid; UNII-M5TZP1RWIE; 4-Piperidinecarboxylic acid; Hexahydroisonicotinic acid; EINECS 207-872-3; MFCD00006004; Isonipecoticacid
Molecular FormulaC6H11NO2
Molecular Weight129.16
Purity97%
Density1.1±0.1 g/cm3
Boiling Point265.8±33.0 °C at 760 mmHg
Melting Point>300 °C (lit.)
AppearanceWhite to light pink-beige powder
EINECS207-872-3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 498-94-2 |
| Catalog No. | 2A-9007646 |
| Chinese Name | 4-哌啶甲酸 |
| Synonyms | Isonipecotic acid; 4-Hexahydroisonicotinic acid; Piperidine-4-carboxylic acid; UNII-M5TZP1RWIE; 4-Piperidinecarboxylic acid; Hexahydroisonicotinic acid; EINECS 207-872-3; MFCD00006004; Isonipecoticacid |
| Molecular Formula | C6H11NO2 |
| Molecular Weight | 129.16 |
| Purity | 97 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 265.8±33.0 °C at 760 mmHg |
| Melting Point | >300 °C (lit.) |
| Appearance | White to light pink-beige powder |
| Water Solubility | soluble |
| Storage Condition | Store sealed and placed in a ventilated, dry envir |
| Application | Isononanoic acid is a partial agonist of GABAA receptors [1]. |
| EINECS | 207-872-3 |
| HTC | 2942000000 |
| PubChem ID | 24278166 |
| MDL Number | MFCD00006004 |
| SMILES | OC(=O)C1CCNCC1 |
| InChI | 1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9) |
| InChI Key | SRJOCJYGOFTFLH-UHFFFAOYSA-N |
| Beilstein/REAXYS | 112553 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Bioactivity | Isonipecotic acid is a GABAA receptor partial agonist[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor Target GABAA Receptor[1] In Vitro Isonipecotic acid inhibits [3H]GABA binding (2°C) with an IC50 of 0.33 μM[2]. References [1]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5. [2]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan;44(1):68-75. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 265.8±33.0 °C at 760 mmHg Melting Point >300 °C(lit.) Molecular Formula C6H11NO2 Molecular Weight 129.157 Flash Point 114.5±25.4 °C Exact Mass 129.078979 PSA 49.33000 LogP -0.08 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.479 InChIKey SRJOCJYGOFTFLH-UHFFFAOYSA-N SMILES O=C(O)C1CCNCC1 Storage condition Store at 0-5°C Water Solubility soluble |
| Use of | Isonipecotic acid is a GABAA receptor partial agonist[1]. Properties Name Isonipecotic acid Synonym More Synonyms Isonipecotic acid Biological Activity Description Isonipecotic acid is a GABAA receptor partial agonist[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor GABAA Receptor[1] References [1]. Krehan D, et al. Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int. 2003 Jun;42(7):561-5. [2]. Falch E, et al. GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid. J Neurochem. 1985 Jan;44(1):68-75. Chemical & Physical Properties Molecular Formula C6H11NO2 Exact Mass 129.078979 PSA 49.33000 LogP -0.08 Index of Refraction 1.479 InChIKey SRJOCJYGOFTFLH-UHFFFAOYSA-N Water Solubility soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| DL-Cystein | 3374-22-9 | 2A-9007640 |
| DL-Cystein hydrochloride hydrate | 116797-51-4 | 2A-9007641 |
| DL-Ethyl 2-bromobutyrate | 533-68-6 | 2A-9007642 |
| D-Leucine | 328-38-1 | 2A-9007643 |
| D-Leucine methyl ester hydrochloride | 5845-53-4 | 2A-9007644 |
| DL-Malic acid dimethyl ester | 38115-87-6 | 2A-9007647 |
| DL-Pipecolinic acid | 535-75-1 | 2A-9007649 |
| DL-Serine methyl ester hydrochloride | 5619-04-5 | 2A-9007650 |
| D-Lysine hydrochloride | 7274-88-6 | 2A-9007652 |
| D-Malic acid | 636-61-3 | 2A-9007653 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS