CAS Number328-38-1
Synonymsleucine; D-Leucine; MFCD00063088; (R)-2-Amino-4-methylpentanoic acid; (2R)-2-amino-4-methylpentanoic acid; ent-1; H-Leu-OH; D-Homo-valine; D-2-Amino-4-methylvaleric acid; H-D-Leu-OH; (R)-2-Amino-4-methyl-pentanoic acid; EINECS 206-327-7; D-2-Amino-4-methylpentanoicacid
Molecular Formula(CH3)2CHCH2CH(NH2)CO2H
Molecular Weight131.17
Purity99%
Density1.0±0.1 g/cm3
Boiling Point225.8±23.0 °C at 760 mmHg
Melting Point>300 °C (lit.)
Appearancepowder (crystals)
EINECS206-327-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 328-38-1 |
| Catalog No. | 2A-9007643 |
| Chinese Name | D-亮氨酸 |
| Synonyms | leucine; D-Leucine; MFCD00063088; (R)-2-Amino-4-methylpentanoic acid; (2R)-2-amino-4-methylpentanoic acid; ent-1; H-Leu-OH; D-Homo-valine; D-2-Amino-4-methylvaleric acid; H-D-Leu-OH; (R)-2-Amino-4-methyl-pentanoic acid; EINECS 206-327-7; D-2-Amino-4-methylpentanoicacid |
| Molecular Formula | (CH3)2CHCH2CH(NH2)CO2H |
| Molecular Weight | 131.17 |
| Purity | 99 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 225.8±23.0 °C at 760 mmHg |
| Melting Point | >300 °C (lit.) |
| Appearance | powder (crystals) |
| Storage Condition | Should be sealed and stored dry. |
| Application | D-Leucine has anti-epileptic activity and is more active than L-leucine. D-leucine effectively terminates epileptic seizures. In vitro, D-Leucine can reduce long-term site formation, but has no effect |
| EINECS | 206-327-7 |
| HTC | 2922499990 |
| PubChem ID | 24888380 |
| MDL Number | MFCD00063088 |
| SMILES | CC(C)C[C@@H](N)C(O)=O |
| InChI | 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1 |
| InChI Key | ROHFNLRQFUQHCH-RXMQYKEDSA-N |
| Beilstein/REAXYS | 1721721 |
| NACRES Code | NA.22 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/7643_2_328_38_1.pdf |
| Bioactivity | D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1]. Related Catalog Research Areas >> Neurological Disease Target Human Endogenous Metabolite In Vitro In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1]. References [1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193 Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 225.8±23.0 °C at 760 mmHg Melting Point > 300ºC Molecular Formula C6H13NO2 Molecular Weight 131.173 Flash Point 90.3±22.6 °C Exact Mass 131.094635 PSA 63.32000 LogP 0.73 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.463 InChIKey ROHFNLRQFUQHCH-RXMQYKEDSA-N SMILES CC(C)CC(N)C(=O)O |
| Use of | D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1]. Properties Name D-leucine Synonym More Synonyms H-D-Leu-OH Biological Activity Description D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1]. Related Catalog Research Areas >> Neurological Disease Human Endogenous Metabolite In Vitro In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1]. References [1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193 Chemical & Physical Properties Molecular Formula C6H13NO2 Exact Mass 131.094635 PSA 63.32000 Index of Refraction 1.463 InChIKey ROHFNLRQFUQHCH-RXMQYKEDSA-N SMILES CC(C)CC(N)C(=O)O |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| DL-3-(3,4-Dimethoxyphenyl)-2-methylalanine | 10128-06-0 | 2A-9007636 |
| DL-4-Amino-3-hydroxybutyric acid | 352-21-6 | 2A-9007637 |
| DL-Cystein | 3374-22-9 | 2A-9007640 |
| DL-Cystein hydrochloride hydrate | 116797-51-4 | 2A-9007641 |
| DL-Ethyl 2-bromobutyrate | 533-68-6 | 2A-9007642 |
| D-Leucine methyl ester hydrochloride | 5845-53-4 | 2A-9007644 |
| DL-Isopipecolinic acid | 498-94-2 | 2A-9007646 |
| DL-Malic acid dimethyl ester | 38115-87-6 | 2A-9007647 |
| DL-Pipecolinic acid | 535-75-1 | 2A-9007649 |
| DL-Serine methyl ester hydrochloride | 5619-04-5 | 2A-9007650 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS