CAS Number141396-28-3
SynonymsArgatroban; MFCD00895735; Argatroban monohydrate; Argatroban anhydrous; UNII:IY90U61Z3S; UNII:OCY3U280Y3; Argatroban (monohydrate)
Molecular FormulaC23H38O6N6S1
Molecular Weight526.66
Density1.5±0.1 g/cm3
Boiling Point801.3±75.0 °C at 760 mmHg
Melting Point-41.5 °C
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 141396-28-3 |
| Catalog No. | 2A-9076166 |
| Chinese Name | 阿加曲班 |
| Synonyms | Argatroban; MFCD00895735; Argatroban monohydrate; Argatroban anhydrous; UNII:IY90U61Z3S; UNII:OCY3U280Y3; Argatroban (monohydrate) |
| Molecular Formula | C23H38O6N6S1 |
| Molecular Weight | 526.66 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 801.3±75.0 °C at 760 mmHg |
| Melting Point | -41.5 °C |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Water solubility: insoluble; slightly soluble: met |
| Storage Condition | 2-8°C |
| Application | Argatroban monohydrate is a selective thrombin inhibitor. |
| HTC | 2935009090 |
| MDL Number | MFCD00895735 |
| SMILES | CC1CNc2c(cccc2S(=O)(=O)NC(CCCN=C(N)N)C(=O)N2CCC(C)CC2C(=O)O)C1.O |
| InChI | InChI=1S/C23H36N6O5S.H2O/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19;/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26);1H2/t14-,15?,17?,18-;/m1./s1 |
| InChI Key | AIEZTKLTLCMZIA-CZSXTPSTSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/76166_1_141396_28_3.pdf |
| Bioactivity | Argatroban monohydrate is a direct, selective thrombin inhibitor.Target: ThrombinArgatroban may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of argatroban is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries [1]. Argatroban, as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Cardiovascular Disease References [1]. Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47(3): p. 104-9. [2]. Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33(7): p. 1879-85. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 801.3±75.0 °C at 760 mmHg Melting Point -41.5 °C Molecular Formula C23H38N6O6S Molecular Weight 526.65 Flash Point 438.4±37.1 °C PSA 195.32000 LogP 2.56 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.674 InChIKey AIEZTKLTLCMZIA-CZSXTPSTSA-N SMILES CC1CNc2c(cccc2S(=O)(=O)NC(CCCN=C(N)N)C(=O)N2CCC(C)CC2C(=O)O)C1.O Storage condition 2-8°C |
| Use of | Properties Name Argatroban Monohydrate Synonym More Synonyms Argatroban Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Cardiovascular Disease References [1]. Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47(3): p. 104-9. [2]. Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33(7): p. 1879-85. Chemical & Physical Properties Molecular Formula C23H38N6O6S PSA 195.32000 Index of Refraction 1.674 InChIKey AIEZTKLTLCMZIA-CZSXTPSTSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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