CAS Number76-22-2
Synonyms(+)-bornan-2-one; camphanone; 3-Fluor-2,2-dimethyl-bicyclo<2.2.1>heptan; (1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; 1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone; 2-Kamfanon; D-CAMPHOR; (±)-bornan-2-one; 2-Oxo-bornan; 2-Bornanone,2-Camphanone,D-Camphor; Radian B; lphanon; DL-2-Bornanone; D-(+)-Camphor; MFCD00676613; Alphanon; L(-)-Camphor; 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; DL-Camphor; Camphen-hydrofluorid; (1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one; Caladryl; (-)-Camphor; 2-Keto-1,7,7-trimethylnolcamphane; (−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; 2-CAMPHOR; EINECS 200-945-0; (±)-Camphor; 2-Camphonone; Dehydrocamphor
Molecular FormulaC10H16O
Molecular Weight152.23
Purity96%
Density1.0±0.1 g/cm3
Boiling Point204 °C (lit.)
Melting Point175-177 °C (lit.)
AppearanceColorless or white crystalline powder with a strong mothball-like odor
EINECS200-945-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76-22-2 |
| Catalog No. | 2A-9007360 |
| Chinese Name | (±)-樟脑(合成) |
| Synonyms | (+)-bornan-2-one; camphanone; 3-Fluor-2,2-dimethyl-bicyclo<2.2.1>heptan; (1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; 1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone; 2-Kamfanon; D-CAMPHOR; (±)-bornan-2-one; 2-Oxo-bornan; 2-Bornanone,2-Camphanone,D-Camphor; Radian B; lphanon; DL-2-Bornanone; D-(+)-Camphor; MFCD00676613; Alphanon; L(-)-Camphor; 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; DL-Camphor; Camphen-hydrofluorid; (1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one; Caladryl; (-)-Camphor; 2-Keto-1,7,7-trimethylnolcamphane; (−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one; 2-CAMPHOR; EINECS 200-945-0; (±)-Camphor; 2-Camphonone; Dehydrocamphor |
| Molecular Formula | C10H16O |
| Molecular Weight | 152.23 |
| Purity | 96 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 204 °C (lit.) |
| Melting Point | 175-177 °C (lit.) |
| Appearance | Colorless or white crystalline powder with a strong mothball-like odor |
| Water Solubility | 0.12 g/100 mL (25 ºC) |
| Storage Condition | Storage precautions: Store in a cool, ventilated w |
| Packaging | III |
| Application | Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic agent with carminative properties when taken orally. However, Camphor is toxic when ingested. Camphor has antiviral, antitussive and |
| EINECS | 200-945-0 |
| HTC | 2914291000 |
| UN(IATA) | UN 2717;1130 |
| PubChem ID | 24848879 |
| MDL Number | MFCD00074738 |
| SMILES | [H][C@](CC1=O)(CC2)C(C)(C)[C@]12C |
| InChI | 1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1 |
| InChI Key | DSSYKIVIOFKYAU-XCBNKYQSSA-N |
| Beilstein/REAXYS | 1907611 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 4.1 |
| Risk Codes | R11;R36/37/38 |
| Safety Description | S16;S26;S37/39 |
| MSDS | msds/7360_2_76_22_2.pdf |
| Bioactivity | Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Infection Target TRPV3[2] In Vitro Camphor induces fibroblast proliferation through the PI3K/AKT and ERK signaling pathways. The MTT assay results show that 32.5, 65, 130, and 260 μM Camphor increase fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM Camphor treatment. Camphor treatment for 24 h increases the generation of ROS by up to 17.97% compared to 5.04% in the no-treatment control[3]. Cell Assay Primary dermal fibroblast (2×104 cells/mL) cells are plated in 96-well plates in 200μL of medium containing 10% FBS. After 24 h, the cells are treated with various concentrations of chamomile hydrosol or Camphor (0-260 μM). After treatment, 20 μL of MTT solution (5mg/mL) is added to each well, followed by incubation in a humidified environment for 3-4 h. The supernatant is removed and 150 μL of DMSO is added. Cell viability is determined from the absorbance at 570 nm, measured using a Sunrise microplate reader[3]. References [1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54. [2]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74. [3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 207.4±0.0 °C at 760 mmHg Melting Point 175-177 °C(lit.) Molecular Formula C10H16O Molecular Weight 152.233 Flash Point 64.4±0.0 °C Exact Mass 152.120117 PSA 17.07000 LogP 2.13 Vapour density 5.2 (vs air) Vapour Pressure 0.2±0.4 mmHg at 25°C Index of Refraction 1.485 InChIKey DSSYKIVIOFKYAU-UHFFFAOYSA-N SMILES CC12CCC(CC1=O)C2(C)C Stability Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics. Water Solubility 0.12 g/100 mL (25 ºC) |
| Use of | Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2]. Properties Articles63 Name camphor Synonym More Synonyms (±)-Camphor Biological Activity Description Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Infection References [1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54. [3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25. Chemical & Physical Properties Molecular Formula C10H16O Exact Mass 152.120117 PSA 17.07000 Vapour density 5.2 (vs air) Index of Refraction 1.485 InChIKey DSSYKIVIOFKYAU-UHFFFAOYSA-N Stability Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics. |
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