CAS Number5579-84-0
SynonymsMFCD00012813; N-Methyl-2-(2-pyridinyl)ethanamine dihydrochloride; N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride; 2-Pyridineethanamine, N-methyl-, hydrochloride (1:2); Betahistine Hydrochloride; N-Methyl-2-pyridineethanamine Dihydrochloride; N-methyl-2-pyridin-2-ylethanamine,dihydrochloride; EINECS 226-966-5; Betahistine (dihydrochloride)
Molecular FormulaC8H14Cl2N2
Molecular Weight209.12
Purity≥98%
Density0.967 g/cm3
Boiling Point210.9ºC at 760 mmHg
Melting Point150-154 °C
Appearancepowder
EINECS226-966-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5579-84-0 |
| Catalog No. | 2A-9007226 |
| Chinese Name | 盐酸倍他司汀 |
| Synonyms | MFCD00012813; N-Methyl-2-(2-pyridinyl)ethanamine dihydrochloride; N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride; 2-Pyridineethanamine, N-methyl-, hydrochloride (1:2); Betahistine Hydrochloride; N-Methyl-2-pyridineethanamine Dihydrochloride; N-methyl-2-pyridin-2-ylethanamine,dihydrochloride; EINECS 226-966-5; Betahistine (dihydrochloride) |
| Molecular Formula | C8H14Cl2N2 |
| Molecular Weight | 209.12 |
| Purity | ≥98 |
| Density | 0.967 g/cm3 |
| Boiling Point | 210.9ºC at 760 mmHg |
| Melting Point | 150-154 °C |
| Appearance | powder |
| Storage Condition | Sealed and stored in a cool, dry warehouse. |
| Application | Betahistine dihydrochloride is a histamine H3 receptor inhibitor. |
| EINECS | 226-966-5 |
| HTC | 2933399090 |
| PubChem ID | 57653935 |
| MDL Number | MFCD00012813 |
| SMILES | Cl.CNCCc1ccccn1 |
| InChI | 1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H |
| InChI Key | XVDFMHARQUBJRE-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Safety Description | S24/25 |
| MSDS | msds/7226_1_5579_84_0.pdf |
| Bioactivity | Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug.Target: Histamine ReceptorBetahistine, a structural analogue of histamine with weak histamine H(1) receptor agonist and more potent H(3) receptor antagonist properties. Betahistine acts centrally by enhancing histamine synthesis within tuberomammillary nuclei of the posterior hypothalamus and histamine release within vestibular nuclei through antagonism of H(3) autoreceptors [1].Therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). On inhibition of cAMP formation and [(3)H]arachidonic acid release, betahistine behaved as a nanomolar inverse agonist and a micromolar agonist. After acute oral administration, Betahistine increased t-MeHA levels with an ED(50) of 2 mg/kg, a rightward shift probably caused by almost complete first-pass metabolism. Therapeutic effects of betahistine result from an enhancement of histamine neuron activity induced by inverse agonism at H(3) autoreceptors [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. Lacour, M. and O. Sterkers, Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs, 2001. 15(11): p. 853-70. [2]. Gbahou, F., et al., Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. J Pharmacol Exp Ther, 2010. 334(3): p. 945-54. Chemical & Physical Properties Density 0.967 g/cm3 Boiling Point 210.9ºC at 760 mmHg Melting Point 150-154 °C Molecular Formula C8H14Cl2N2 Molecular Weight 209.116 Flash Point 96.7ºC Exact Mass 208.053406 PSA 24.92000 LogP 2.83840 InChIKey XVDFMHARQUBJRE-UHFFFAOYSA-N SMILES CNCCc1ccccn1.Cl.Cl |
| Use of | Properties Articles27 Name Betahistine dihydrochloride Synonym More Synonyms Betahistine Dihydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. Lacour, M. and O. Sterkers, Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. CNS Drugs, 2001. 15(11): p. 853-70. [2]. Gbahou, F., et al., Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. J Pharmacol Exp Ther, 2010. 334(3): p. 945-54. Chemical & Physical Properties Exact Mass 208.053406 PSA 24.92000 LogP 2.83840 InChIKey XVDFMHARQUBJRE-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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