CAS Number441067-49-8
Synonyms(4S)-4-Hydroxy-L-proline hydrochloride (1:1); (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride; (4R)-4-Hydroxy-D-proline hydrochloride (1:1); cis-4-Hydroxy-L-proline Hydrochloride; L-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1); (4S)-4-hydroxy-L-proline hydrochloride; D-Proline, 4-hydroxy-, (4R)-, hydrochloride (1:1)
Molecular FormulaC5H10O3N1Cl1
Molecular Weight167.59
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 441067-49-8 |
| Catalog No. | 2A-9071668 |
| Chinese Name | (4S)-4-羟基-L-脯氨酸盐酸盐 |
| Synonyms | (4S)-4-Hydroxy-L-proline hydrochloride (1:1); (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride; (4R)-4-Hydroxy-D-proline hydrochloride (1:1); cis-4-Hydroxy-L-proline Hydrochloride; L-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1); (4S)-4-hydroxy-L-proline hydrochloride; D-Proline, 4-hydroxy-, (4R)-, hydrochloride (1:1) |
| Molecular Formula | C5H10O3N1Cl1 |
| Molecular Weight | 167.59 |
| Storage Condition | room temperature |
| Application | Cis-4-hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). Cis-4-hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that ca |
| HTC | 2933990090 |
| PubChem ID | 46117321 |
| MDL Number | MFCD09953187 |
| SMILES | Cl.O=C(O)C1CC(O)CN1 |
| InChI | InChI=1S/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m0./s1 |
| InChI Key | YEJFFQAGTXBSTI-MMALYQPHSA-N |
| MSDS | msds/71668_1_441067_49_8.pdf |
| Bioactivity | cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C5H10ClNO3 Molecular Weight 167.591 Exact Mass 167.034927 PSA 69.56000 InChIKey YEJFFQAGTXBSTI-MMALYQPHSA-N SMILES Cl.O=C(O)C1CC(O)CN1 |
| Use of | cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Properties Name (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride Synonym More Synonyms cis-4-Hydroxy-L-proline hydrochloride Biological Activity Description cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Exact Mass 167.034927 PSA 69.56000 InChIKey YEJFFQAGTXBSTI-MMALYQPHSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 2-(4-tert-Butyl-phenyl)-2-methyl-propionicacidmethylester | 157444-69-4 | 2A-9071640 |
| 4-Bromo-2-phenylypridine | 98420-98-5 | 2A-9071642 |
| 3,4,5-Trifluorophenylalanine | 261952-26-5 | 2A-9071660 |
| D-2,6-Difluorophenylalanine, | 266360-62-7 | 2A-9071661 |
| N-(3-Fluoro-phenyl)-2,2-dimethyl-propionamide | 81740-17-2 | 2A-9071662 |
| trans-4-Hydroxy-D-prolinehydrochloride | 142347-81-7 | 2A-9071669 |
| 2-Amino-5-bromo-4-pyrimidinol | 61937-71-1 | 2A-9071682 |
| (6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-aceticacid | 57351-00-5 | 2A-9071685 |
| 2-[3-Methyl-2-(methylimino)-4-oxo-1,3-thiazolan-5-yl]aceticacid | 41306-29-0 | 2A-9071688 |
| Ethyl2-(1-benzylpiperidin-4-ylidene)acetate | 40110-55-2 | 2A-9071689 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS