CAS Number57248-88-1
SynonymsDisodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]; Pamidronate disodium salt; Pamidronate disodium; Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2); Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]; APD; Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate; MFCD01938386; EINECS 260-647-1; (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium; Pamidronate (Disodium)
Molecular FormulaC3H11NNa2O7P2
Molecular Weight279.03 (anhydrous basis)
Purity≥95 (NMR)%
Melting Point300 °C
Appearancesolid
EINECS260-647-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57248-88-1 |
| Catalog No. | 2A-9007108 |
| Chinese Name | 帕米膦酸二钠 |
| Synonyms | Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]; Pamidronate disodium salt; Pamidronate disodium; Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2); Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]; APD; Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate; MFCD01938386; EINECS 260-647-1; (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium; Pamidronate (Disodium) |
| Molecular Formula | C3H11NNa2O7P2 |
| Molecular Weight | 279.03 (anhydrous basis) |
| Purity | ≥95 (NMR) |
| Melting Point | 300 °C |
| Appearance | solid |
| Water Solubility | H2O: 28 mg/mL |
| Storage Condition | 2-8°C |
| Application | Pamidronate disodium salt strengthens bones. |
| EINECS | 260-647-1 |
| HTC | 2931900090 |
| PubChem ID | 24724574 |
| MDL Number | MFCD11045314 |
| SMILES | O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O |
| InChI | 1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2 |
| InChI Key | TVQNUQCYOOJTMK-UHFFFAOYSA-L |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Xn |
| Risk Codes | R22 |
| MSDS | msds/7108_1_57248_88_1.pdf |
| Use of | Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone. Properties Name Disodium Pamidronate Hydrate Synonym More Synonyms Pamidronate disodium Biological Activity Description Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.Target: OthersPamidronate belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) by people who have cancer. Pamidronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours and multiple myeloma (cancer of the bone marrow). Pamidronate is also used to treat the symptoms of Paget's disease of bone. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Zarychanski, R., et al., Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol, 2006. 81(1): p. 73-5. Chemical & Physical Properties Molecular Formula C3H11NNa2O7P2 PSA 186.59000 Appearance of Characters solid | white InChIKey MXOIKYVGQDEWSQ-UHFFFAOYSA-N SMILES NCCC(O)(P(=O)(O)O)P(=O)(O)O.[Na] Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt CAS REGISTRY NUMBER : 57248-88-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C3-H9-N-O7-P2.2Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : 750 ug/kg/5D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Sense Organs and Special Senses (Eye) - effect, not otherwise specified REFERENCE : ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,320,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 600 ug/kg/6H-C TOXIC EFFECTS : Nutritional and Gross Metabolic - changes in calcium REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,622,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Musculoskeletal - joints REFERENCE : APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 31,499,1997 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992 Safety Information Hazard Codes Xn WGK Germany 3 RTECS SZ6525000 HS Code 2931900090 |
| Tax Rebate | 13.0% |
| Supervision | AB (Inbound cargo customs clearance form) |
| Transport Info | Product name: Pamidronate disodium |
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