CAS Number115-46-8
Synonymsalpha,alpha-Diphenyl-4-piperidinomethanol; 4-(α,α Diphenyl) piperidine methanol; Diphenyl(4-piperidinyl)methanol; a,a-Diphenyl-4-piperidinemethanol; γ-Pipradrol; MFCD00066980; Ataractan; α,α-Diphenyl-4-piperidinemethanol; α-(4-Piperidyl)benzhydrol; azacyclonol; diphenyl(4-piperidyl)methanol; Psychosan; g-Pipradrol; diphenyl(piperidin-4-yl)methanol; α,α-Diphenyl-4-piperidinomethanol; Diphenyl (g-Pyridyl)carbinol; a-(4-Piperidyl)benzhydrol; 4-(Diphenylhydroxymethyl)piperidine; EINECS 204-092-5; Calmeran
Molecular FormulaC18H21NO
Molecular Weight267.37
Purity99%
Density1.1±0.1 g/cm3
Boiling Point445.5±40.0 °C at 760 mmHg
Melting Point160-163 °C
Appearancesolid
EINECS204-092-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 115-46-8 |
| Catalog No. | 2A-9007092 |
| Chinese Name | 二苯基(4-哌啶基)甲醇 |
| Synonyms | alpha,alpha-Diphenyl-4-piperidinomethanol; 4-(α,α Diphenyl) piperidine methanol; Diphenyl(4-piperidinyl)methanol; a,a-Diphenyl-4-piperidinemethanol; γ-Pipradrol; MFCD00066980; Ataractan; α,α-Diphenyl-4-piperidinemethanol; α-(4-Piperidyl)benzhydrol; azacyclonol; diphenyl(4-piperidyl)methanol; Psychosan; g-Pipradrol; diphenyl(piperidin-4-yl)methanol; α,α-Diphenyl-4-piperidinomethanol; Diphenyl (g-Pyridyl)carbinol; a-(4-Piperidyl)benzhydrol; 4-(Diphenylhydroxymethyl)piperidine; EINECS 204-092-5; Calmeran |
| Molecular Formula | C18H21NO |
| Molecular Weight | 267.37 |
| Purity | 99 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 445.5±40.0 °C at 760 mmHg |
| Melting Point | 160-163 °C |
| Appearance | solid |
| Storage Condition | Room temperature, dry |
| Application | Azacyclonol, γ-pipradol, has the activity of eliminating hallucinations in patients with psychosis. |
| EINECS | 204-092-5 |
| HTC | 29333999 |
| MDL Number | MFCD00066980 |
| SMILES | OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCNCC3 |
| InChI | 1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2 |
| InChI Key | ZMISODWVFHHWNR-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Xi |
| Risk Codes | R36/37/38 |
| Safety Description | S24/25 |
| MSDS | msds/7092_1_115_46_8.pdf |
| Bioactivity | Azacyclonol, also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.Target: OthersAzacyclonol is a drug which is a so-called ataractive, or agent which diminishes hallucinations in psychotic individuals. The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver [1]. The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1 [2]. The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing [3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Raeissi, S.D., et al., Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine. Pharm Res, 1997. 14(8): p. 1019-25. [2]. Ling, K.H., et al., Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug Metab Dispos, 1995. 23(6): p. 631-6. [3]. Brown, D.A. and J.P. Quilliam, The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother, 1964. 23(2): p. 241-56. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 445.5±40.0 °C at 760 mmHg Melting Point 160-163 °C Molecular Formula C18H21NO Molecular Weight 267.365 Flash Point 142.0±18.0 °C Exact Mass 267.162323 PSA 32.26000 LogP 3.25 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.584 InChIKey ZMISODWVFHHWNR-UHFFFAOYSA-N SMILES OC(c1ccccc1)(c1ccccc1)C1CCNCC1 |
| Use of | Properties Name Diphenyl(piperidin-4-yl)methanol Synonym More Synonyms Azacyclonol Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [2]. Ling, K.H., et al., Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes. Drug Metab Dispos, 1995. 23(6): p. 631-6. [3]. Brown, D.A. and J.P. Quilliam, The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother, 1964. 23(2): p. 241-56. Chemical & Physical Properties Molecular Formula C18H21NO Exact Mass 267.162323 PSA 32.26000 Index of Refraction 1.584 InChIKey ZMISODWVFHHWNR-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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