CAS Number6836-19-7
SynonymsEINECS 229-916-0; 3,4-dihydro-7-methoxynaphthalen-1(2H)-one; 7-Methoxy-3,4-dihydronaphthalen-1(2H)-one; MFCD00001696; 7-Methoxy-3,4-dihydro-1(2H)-naphthalenone; 7-methoxy-3,4-dihydro-2H-naphthalen-1-one
Molecular FormulaC11H12O2
Molecular Weight176.21
Purity97%
Density1.1±0.1 g/cm3
Boiling Point160-162 °C/7 mmHg (lit.)
Melting Point87-91 °C (lit.)
Appearancesolid
EINECS251-723-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6836-19-7 |
| Catalog No. | 2A-9006983 |
| Chinese Name | 7-甲氧基-1-萘满酮 |
| Synonyms | EINECS 229-916-0; 3,4-dihydro-7-methoxynaphthalen-1(2H)-one; 7-Methoxy-3,4-dihydronaphthalen-1(2H)-one; MFCD00001696; 7-Methoxy-3,4-dihydro-1(2H)-naphthalenone; 7-methoxy-3,4-dihydro-2H-naphthalen-1-one |
| Molecular Formula | C11H12O2 |
| Molecular Weight | 176.21 |
| Purity | 97 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 160-162 °C/7 mmHg (lit.) |
| Melting Point | 87-91 °C (lit.) |
| Appearance | solid |
| Storage Condition | 2~8°C |
| Application | 7-Methoxy-1-tetralone is an effective antitumor drug. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration and induces apoptosis in hepatocellular carcinoma cells (HCC). 7-Methoxy-1- |
| EINECS | 251-723-5 |
| HTC | 2914509090 |
| PubChem ID | 24847133 |
| MDL Number | MFCD00001692 |
| SMILES | COc1cccc2C(=O)CCCc12 |
| InChI | 1S/C11H12O2/c1-13-11-7-3-4-8-9(11)5-2-6-10(8)12/h3-4,7H,2,5-6H2,1H3 |
| InChI Key | BRCPWISABURVIH-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2047383 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/6983_1_6836_19_7.pdf |
| Bioactivity | 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR In Vitro 7-Methoxy-1-tetralone (31.25-1000 μM; 48 h) inhibits the proliferation activity of LO2 and HepG2 cells [1]. 7-Methoxy-1-tetralone (40 μM, 100 μM, 250 μM; 48 h) induces apoptosis in HepG2 cells and regulates the expression levels of c-Met, p-AKT, AKT, NF-κB, MMP2, and MMP9 proteins in the cells [1]. Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 40 μM, 100 μM, and 250 μM Incubation Time: 48 h Result: Decreased the protein expression levels of c-Met, p-AKT, NF-κB, MMP2, and MMP9. Cell Proliferation Assay[1] Cell Line: LO2 and HepG2 cells Concentration: 31.25 μM, 62.5 μM, 125 μM, 250 μM, 500 μM, and 1000 μM Incubation Time: 24 h, 48 h, and 72 h Result: Exhibited anti-proliferative activity of MT on LO2 and HepG2 cells. In Vivo 7-Methoxy-1-tetralone (80, 120, or 160 mg/kg/d; i.p.; 19 doses total) inhibits tumor growth in tumor models in which HepG2 cells are implanted subcutaneously [1]. Animal Model: BALB/c nude mice (5-week-old) with subcutaneously implanted HepG2 cells[1] Dosage: 80, 120, or 160 mg/kg/d Administration: Intraperitoneal injection; sacrificed after 19 days Result: Resulted the tumor inhibition rates of 40.57% (80 mg/kg), 51.43% (120 mg/kg), 79.43% (160 mg/kg), respectively. References [1]. Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 312.3±31.0 °C at 760 mmHg Melting Point 59-63 °C(lit.) Molecular Formula C11H12O2 Molecular Weight 176.21 Flash Point 145.8±18.4 °C Exact Mass 176.083725 PSA 26.30000 LogP 2.79 Vapor Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.549 InChIKey GABLTKRIYDNDIN-UHFFFAOYSA-N SMILES COc1ccc2c(c1)C(=O)CCC2 Storage condition 2~8°C |
| Use of | 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1]. Properties Name 7-Methoxy-1-tetralone Synonym More Synonyms 7-Methoxy-1-tetralone Biological Activity Description 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR References [1]. Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58. Chemical & Physical Properties Molecular Formula C11H12O2 Exact Mass 176.083725 PSA 26.30000 Index of Refraction 1.549 InChIKey GABLTKRIYDNDIN-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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