CAS Number41137-87-5
Synonymschikusetsusaponinivc; Panaxoside; hirsutanone; Ginsenoside Re std.; gingerenone-A; gingenoside Re; ginsenoside-Re standard; ginsenoside-Re; (4E)-1,7-Bis(3,4-dihydroxyphenyl)hept-4-en-3-one; GINSENOSIDE GINSENOSIDE-RE; (4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one; 1,7-Bis-(3,4-dihydroxy-phenyl)-hept-4-en-3-one; ginsenosideb2; Hirsutenone
Molecular FormulaC19H20O5
Molecular Weight328.36
Purity≥95 (LC/MS-ELSD)%
Density1.3±0.1 g/cm3
Boiling Point622.0±55.0 °C at 760 mmHg
Appearancesolid
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 41137-87-5 |
| Catalog No. | 2A-9069012 |
| Chinese Name | (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮 |
| Synonyms | chikusetsusaponinivc; Panaxoside; hirsutanone; Ginsenoside Re std.; gingerenone-A; gingenoside Re; ginsenoside-Re standard; ginsenoside-Re; (4E)-1,7-Bis(3,4-dihydroxyphenyl)hept-4-en-3-one; GINSENOSIDE GINSENOSIDE-RE; (4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one; 1,7-Bis-(3,4-dihydroxy-phenyl)-hept-4-en-3-one; ginsenosideb2; Hirsutenone |
| Molecular Formula | C19H20O5 |
| Molecular Weight | 328.36 |
| Purity | ≥95 (LC/MS-ELSD) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 622.0±55.0 °C at 760 mmHg |
| Appearance | solid |
| Storage Condition | ?20°C |
| Application | Hirsutenone is an active diheptanone contained in alder, which has various biological activities such as anti-inflammatory, anti-tumor and anti-atopic dermatitis. Hirsutenone attenuates adipogenesis a |
| HTC | 2914501900 |
| PubChem ID | 329824774 |
| MDL Number | MFCD20274778 |
| SMILES | Oc1ccc(CC\C=C\C(=O)CCc2ccc(O)c(O)c2)cc1O |
| InChI | 1S/C19H20O5/c20-15(8-5-14-7-10-17(22)19(24)12-14)4-2-1-3-13-6-9-16(21)18(23)11-13/h2,4,6-7,9-12,21-24H,1,3,5,8H2/b4-2+ |
| InChI Key | VWHYFMQKJYFLCC-DUXPYHPUSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352205 |
| Hazard Symbols | transportation |
| MSDS | msds/69012_1_41137_87_5.pdf |
| Bioactivity | Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK In Vitro Hirsutenone (0-100 μM; 48 hours) inhibits adipogenesis in 3T3-L1 preadipocytes and exhibits non-toxicity at 20-100 μM[1]. Hirsutenone (0-100 μM; 48 hours) attenuates MDI-induced lipid accumulation in 3T3-L1 preadipocytes in a dose-dependent manner. In particular, HST at 40 and 80 μM significantly reduces MDI-induced adipogenesis in 3T3-L1 preadipocytes[1]. Hirsutenone (0-100 μM; 48 hours) reduces the protein expression levels of PPARg, C/EBPa, and FAS in a dose-dependent manner in 3T3-L1 preadipocytes[1]. Hirsutenone (80 μM; 20-24 hours) suppresses the cell cycle entry to S and G2/M phases occurrs at 20 hours when compares with at 20 hours. At 24 h, more cells are arrested in G1 phase (53% of total cells) when compares with the MDI-induced group which contains the majority of cells (56% of total cells) in G2/M phase[1]. References [1]. Lai Yee Cheong, et al. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.J Cell Biochem Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 622.0±55.0 °C at 760 mmHg Molecular Formula C19H20O5 Molecular Weight 328.359 Flash Point 344.0±28.0 °C Exact Mass 328.131073 PSA 97.99000 LogP 2.16 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.649 InChIKey VWHYFMQKJYFLCC-DUXPYHPUSA-N SMILES O=C(C=CCCc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1 Storage condition ?20°C |
| Use of | Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity[1]. Properties Name (4E)-1,7-Bis(3,4-dihydroxyphenyl)-4-hepten-3-one Synonym More Synonyms Hirsutenone Biological Activity Description Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK References [1]. Lai Yee Cheong, et al. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.J Cell Biochem Chemical & Physical Properties Molecular Formula C19H20O5 Exact Mass 328.131073 PSA 97.99000 Index of Refraction 1.649 InChIKey VWHYFMQKJYFLCC-DUXPYHPUSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 United Nations shipping name European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Hirsutenone) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Hirsutenone) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (Hirsutenone) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: Yes Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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