CAS Number127-22-0
SynonymsUNII-A32778O852; D-Friedoolean-14-en-3beta-ol; Isoolean-14-en-3b-ol; alnulin; Skimmiol; D-friedoolean-14-en-3β-ol; Taraxerol; Tiliadin; D-Friedoolean-14-en-3b-ol
Molecular FormulaC30H50O
Molecular Weight426.72
Purity≥95.0 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point490.7±44.0 °C at 760 mmHg
Melting Point282-285°
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 127-22-0 |
| Catalog No. | 2A-9068949 |
| Chinese Name | 蒲公英赛醇 |
| Synonyms | UNII-A32778O852; D-Friedoolean-14-en-3beta-ol; Isoolean-14-en-3b-ol; alnulin; Skimmiol; D-friedoolean-14-en-3β-ol; Taraxerol; Tiliadin; D-Friedoolean-14-en-3b-ol |
| Molecular Formula | C30H50O |
| Molecular Weight | 426.72 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 490.7±44.0 °C at 760 mmHg |
| Melting Point | 282-285° |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | Taraxerol is isolated from dandelion and has anti-inflammatory and anti-cancer properties. Taraxerol reduces acute inflammation by inhibiting the NF-κB signaling pathway. Taraxerol induces apoptosis. |
| PubChem ID | 329766775 |
| MDL Number | MFCD13186859 |
| SMILES | CC1(C)CC[C@]2(C)CC=C3[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@@]3(C)[C@]2([H])C1 |
| InChI | 1S/C30H50O/c1-25(2)17-18-27(5)13-9-21-29(7)14-10-20-26(3,4)24(31)12-16-28(20,6)22(29)11-15-30(21,8)23(27)19-25/h9,20,22-24,31H,10-19H2,1-8H3/t20-,22+,23+,24-,27-,28-,29-,30+/m0/s1 |
| InChI Key | GGGUGZHBAOMSFJ-GADYQYKKSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 85151701 |
| Hazard Symbols | transportation |
| MSDS | msds/68949_1_127_22_0.pdf |
| Bioactivity | Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology Target IC50: apoptosis[1] In Vitro Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells[1]. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages[1]. In Vivo Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment[2]. References [1]. Yaoi X, et al. Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells.Cell J. 2017 Oct;19(3):512-519. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 490.7±44.0 °C at 760 mmHg Melting Point 282-285° Molecular Formula C30H50O Molecular Weight 426.717 Flash Point 217.7±20.7 °C Exact Mass 426.386169 PSA 20.23000 LogP 11.06 Vapour Pressure 0.0±2.8 mmHg at 25°C Index of Refraction 1.539 InChIKey GGGUGZHBAOMSFJ-GADYQYKKSA-N SMILES CC1(C)CCC2(C)CC=C3C(C)(CCC4C3(C)CCC3C(C)(C)C(O)CCC43C)C2C1 Storage condition 2-8℃ |
| Use of | Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. Properties Articles25 Name taraxerol Synonym More Synonyms Taraxerol Biological Activity Description Taraxerol is isolated from Abroma augusta L, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology IC50: apoptosis[1] In Vitro Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells[1]. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages[1]. References [1]. Yaoi X, et al. Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells.Cell J. 2017 Oct;19(3):512-519. Chemical & Physical Properties Molecular Formula C30H50O Exact Mass 426.386169 PSA 20.23000 LogP 11.06 Index of Refraction 1.539 InChIKey GGGUGZHBAOMSFJ-GADYQYKKSA-N Storage condition 2-8℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Loganetin | 29748-10-5 | 2A-9068942 |
| 6-Acetonyl-N-methyl-dihydrodecarine | 1253740-09-8 | 2A-9068943 |
| Sesamoside | 117479-87-5 | 2A-9068945 |
| 12-Ursene-3,16,22-triol | 1242085-06-8 | 2A-9068947 |
| Myricanol | 33606-81-4 | 2A-9068948 |
| Dihydrorobinetin | 4382-33-6 | 2A-9068950 |
| Robtin | 4382-34-7 | 2A-9068952 |
| AnisofolinA | 83529-71-9 | 2A-9068953 |
| Daurichromenicacid | 82003-90-5 | 2A-9068954 |
| 1-(3,4-Dimethoxyphenyl)propane-1,2-diol | 20133-19-1 | 2A-9068955 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS