![(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione-d5 structure, CAS 110351-94-5](/structures/80000/68405_1_110351_94_5.png)
CAS Number110351-94-5
Synonyms(s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione; (4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione; (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
Molecular FormulaC13H13O5N1
Molecular Weight263.25
Purity98%
Density1.5±0.1 g/cm3
Boiling Point666.6±55.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 110351-94-5 |
| Catalog No. | 2A-9068405 |
| Chinese Name | (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃O[3,4-F]吲哚嗪-3,6,10(4H)-酮 |
| Synonyms | (s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione; (4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione; (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione |
| Molecular Formula | C13H13O5N1 |
| Molecular Weight | 263.25 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 666.6±55.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, dry and sealed |
| Application | Exatecan intermediate 1 (compound 6) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent that belongs to the class of camptothecin analogs. Exatecan interferes with the |
| HTC | 2934999090 |
| MDL Number | MFCD09833229 |
| SMILES | CCC1(O)C(=O)OCc2c1cc1n(c2=O)CCC1=O |
| InChI Key | IGKWOGMVAOYVSJ-ZDUSSCGKSA-N |
| MSDS | msds/68405_1_110351_94_5.pdf |
| Use of | Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2]. Properties Name (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione Synonym More Synonyms Biological Activity Description Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin References [1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973. [2]. Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31. Chemical & Physical Properties Molecular Formula C13H13NO5 Exact Mass 263.079376 PSA 85.60000 LogP -0.94 Index of Refraction 1.637 InChIKey IGKWOGMVAOYVSJ-ZDUSSCGKSA-N Safety Information HS Code 2934999090 Synthetic Route (S)-4-Ethyl-4,6... 183434-04-0 (S)-4-ethyl-4-h... 110351-94-5 Literature: Journal of Organic Chemistry, , vol. 62, # 19 p. 6588 - 6597 (4'S)-4'... 110351-93-4 (S)-4-ethyl-4-h... 110351-94-5 Literature: Tetrahedron Asymmetry, , vol. 6, # 6 p. 1245 - 1248 (S)-4'-ethy... 165674-36-2 (S)-4-ethyl-4-h... 110351-94-5 Literature: Tetrahedron Asymmetry, , vol. 6, # 6 p. 1245 - 1248 Precursor & DownStream Precursor 7 CAS#:183434-04-0 (S)-4-Ethyl-4,6... CAS#:110351-93-4 (4'S)-4'-ethyl-... CAS#:165674-36-2 (S)-4'-ethyl-4'... CAS#:110314-10-8 (S)-α-ethyl-α-h... DownStream 10 CAS#:91421-42-0 CAS#:91421-43-1 9-Aminocamptothecin CAS#:86639-52-3 7-Ethyl-10-hydr... CAS#:7689-03-4 Campathecin |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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