CAS Number524-15-2
Synonyms8-Methoxydictamine; 8-Methoxydictamnine; 4,8-Dimethoxyfuro[2,3-b]quinoline; Fagarine; g-fagarine; γ-Fagarine
Molecular FormulaC13H11NO3
Molecular Weight229.231
Density1.3±0.1 g/cm3
Boiling Point381.0±37.0 °C at 760 mmHg
Melting Point142°
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 524-15-2 |
| Catalog No. | 2A-9066626 |
| Chinese Name | gamma-花椒碱 |
| Synonyms | 8-Methoxydictamine; 8-Methoxydictamnine; 4,8-Dimethoxyfuro[2,3-b]quinoline; Fagarine; g-fagarine; γ-Fagarine |
| Molecular Formula | C13H11NO3 |
| Molecular Weight | 229.231 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 381.0±37.0 °C at 760 mmHg |
| Melting Point | 142° |
| Appearance | powder |
| Storage Condition | 2-8℃, dry, sealed |
| Application | γ-Fagarine is a furoquinoline alkaloid found naturally in Rutae Herba and has strong anti-HCV activity with an IC50 of 20.4 μg/mL. It is also a sister chromatid exchange (SCE) inducer. |
| HTC | 2934999090 |
| SMILES | COc1c2ccoc2nc2c(OC)cccc12 |
| InChI | InChI=1S/C13H11NO3/c1-15-10-5-3-4-8-11(10)14-13-9(6-7-17-13)12(8)16-2/h3-7H,1-2H3 |
| InChI Key | KFBCTNNQFGONHB-UHFFFAOYSA-N |
| Use of | γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer[1][2]. Properties Name 4,8-Dimethoxyfuro[2,3-b]quinoline Synonym More Synonyms gamma-Fagarine Biological Activity Description γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer[1][2]. Related Catalog Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection IC50: 20.4 μg/mL (HCV)[1] References [1]. Tutik Sri Wahyuni, et al. Inhibition of Hepatitis C Virus Replication by Chalepin and Pseudane IX Isolated From Ruta Angustifolia Leaves. Fitoterapia. 2014 Dec;99:276-83. [2]. O Schimmer, et al. The SCE-inducing Potency of the Furoquinoline Alkaloid, Gamma-Fagarine, and a Gamma-Fagarine-Containing Tincture From Rutae Herba, in Cultured Human Lymphocytes. Mutagenesis. 1989 Nov;4(6):467-70. Chemical & Physical Properties Molecular Formula C13H11NO3 Exact Mass 229.073898 PSA 44.49000 Index of Refraction 1.643 InChIKey KFBCTNNQFGONHB-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Furo(2,3-b)quinoline, 4,8-dimethoxy- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C13-H11-N-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 ug/plate REFERENCE : MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,349,1988 Safety Information Hazard Codes Xi HS Code 2934999090 Synthetic Route (7S,8R)-4-metho... 865878-14-4 gamma-Fagarine Literature: Boyd, Derek R.; Sharma, Narain D.; O'Dowd, Colin R.; Carroll, Jonathan G.; Loke, Pui L.; Allen, Christopher C. R. Chemical Communications, 2005 , # 31 p. 3989 - 3991 diazomethane 186581-53-3 gamma-Fagarine Literature: Boyd, Derek R.; Sharma, Narain D.; O'Dowd, Colin R.; Carroll, Jonathan G.; Loke, Pui L.; Allen, Christopher C. R. Chemical Communications, 2005 , # 31 p. 3989 - 3991 (7S,8R)-4-metho... 865878-22-4 gamma-Fagarine Literature: Boyd, Derek R.; Sharma, Narain D.; O'Dowd, Colin R.; Carroll, Jonathan G.; Loke, Pui L.; Allen, Christopher C. R. Chemical Communications, 2005 , # 31 p. 3989 - 3991 Precursor & DownStream Precursor 9 CAS#:865878-14-4 (7S,8R)-4-metho... CAS#:186581-53-3 diazomethane CAS#:2255-50-7 CAS#:865878-22-4 (7S,8R)-4-metho... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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