CAS Number42438-89-1
Synonymsmono-methylated resveratrol; 3,4'-Dihydroxy-5-methoxy-trans-stilbene; 3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol; Pinostilbene; Pinostilbene hydrate; 3-methoxyresveratrol; trans-3,4'-dihydroxy-5-methoxystilbene; phenol (3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy; 5,4'-dihydroxy-3-methoxystilbene; trans-Pinostilbene; 3-methoxy-4',5-dihydroxy-trans-stilbene; 4,3'-dihydroxy-5'-methoxystilbene
Molecular FormulaC15H14O3
Molecular Weight242.27 (anhydrous basis)
Purity≥95 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point454.3±33.0 °C at 760 mmHg
Melting Point117-118℃
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 42438-89-1 |
| Catalog No. | 2A-9066492 |
| Chinese Name | 松茋 |
| Synonyms | mono-methylated resveratrol; 3,4'-Dihydroxy-5-methoxy-trans-stilbene; 3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol; Pinostilbene; Pinostilbene hydrate; 3-methoxyresveratrol; trans-3,4'-dihydroxy-5-methoxystilbene; phenol (3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy; 5,4'-dihydroxy-3-methoxystilbene; trans-Pinostilbene; 3-methoxy-4',5-dihydroxy-trans-stilbene; 4,3'-dihydroxy-5'-methoxystilbene |
| Molecular Formula | C15H14O3 |
| Molecular Weight | 242.27 (anhydrous basis) |
| Purity | ≥95 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 454.3±33.0 °C at 760 mmHg |
| Melting Point | 117-118℃ |
| Appearance | powder |
| Water Solubility | DMSO: ≥13mg/mL |
| Storage Condition | 2-8°C |
| Application | Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene has inhibitory effects on colon cancer cells. |
| HTC | 2909500000 |
| PubChem ID | 329825156 |
| MDL Number | MFCD20527315 |
| SMILES | O.COc1cc(O)cc(\C=C\c2ccc(O)cc2)c1 |
| InChI | 1S/C15H14O3.H2O/c1-18-15-9-12(8-14(17)10-15)3-2-11-4-6-13(16)7-5-11;/h2-10,16-17H,1H3;1H2/b3-2+; |
| InChI Key | XZMDLGKACFLROY-SQQVDAMQSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/66492_1_42438_89_1.pdf |
| Bioactivity | Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells[1]. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells[1]. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells[1]. Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis[1]. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells[2]. Cell Viability Assay[1] Cell Line: HCT116 cells, HT29 cells Concentration: 24 hours, 48 hours Incubation Time: 0-100 μM Result: Inhibited the growth of two human colon cancer cells. Apoptosis Analysis[1] Cell Line: HCT116 cells, HT29 cells Concentration: 20 μM, 40 μM Incubation Time: 24 hours, 48 hours Result: Caused a significant and dose-dependent increase in the percentage of cells in S phase. Cell Viability Assay[1] Cell Line: HCT116 cells Concentration: 20 μM,40 μM Incubation Time: 24 hours, 48 hours Result: Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21Cip1/Waf1, while decreased the expression levels of cyclin E and p-Rb. References [1]. Sun Y, et al. Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mol Nutr Food Res. 2016 Sep;60(9):1924-32. [2]. Chao J, et al. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2010 Jun;21(6):482-9. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 454.3±33.0 °C at 760 mmHg Melting Point 117-118℃ Molecular Formula C15H14O3 Molecular Weight 242.270 Flash Point 228.5±25.4 °C Exact Mass 242.094299 PSA 49.69000 LogP 3.80 Appearance of Characters white to tan Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.692 Storage condition 2-8°C Water Solubility DMSO: ≥13mg/mL |
| Use of | Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells[1]. Properties Name 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol Synonym More Synonyms Pinostilbene Biological Activity Description Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Sun Y, et al. Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mol Nutr Food Res. 2016 Sep;60(9):1924-32. [2]. Chao J, et al. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2010 Jun;21(6):482-9. Chemical & Physical Properties Molecular Formula C15H14O3 Exact Mass 242.094299 PSA 49.69000 Appearance of Characters white to tan Index of Refraction 1.692 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (3,4'-Dihydroxy-5- methoxy-trans-stilbene) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (3,4'-Dihydroxy-5- methoxy-trans-stilbene) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (3,4'-Dihydroxy-5-methoxy-trans- stilbene) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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