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QUINAPRILAT HYDRATE structure, CAS 82768-85-2

QUINAPRILAT HYDRATE

CAS Number82768-85-2

Synonymsquinapril diacid; ci928; (3s-(2(r*(r*)),3r*))-yl)amino)-1-oxopropyl); CI-92; 3-isoquinolinecarboxylicacid,1,2,3,4-tetrahydro-2-(2-((1-carboxy-3-phenylprop; quinaprilate

Molecular FormulaC23H26N2O5

Molecular Weight410.46

Purity98%

Density1.289 g/cm3

Boiling Point674.5ºC at 760 mmHg

Melting Point166-168ºC

Flash Point

Appearancecrystalline solid

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Cat. No.: 2A-9061518 Purity: 98%
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Quality Control of [ 82768-85-2 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number82768-85-2
Catalog No.2A-9061518
Chinese Name喹普利拉
Synonymsquinapril diacid; ci928; (3s-(2(r*(r*)),3r*))-yl)amino)-1-oxopropyl); CI-92; 3-isoquinolinecarboxylicacid,1,2,3,4-tetrahydro-2-(2-((1-carboxy-3-phenylprop; quinaprilate
Molecular FormulaC23H26N2O5
Molecular Weight410.46
Purity98
Density1.289 g/cm3
Boiling Point674.5ºC at 760 mmHg
Melting Point166-168ºC
Appearancecrystalline solid
ApplicationQuinapril is an orally active non-thiol angiotensin-converting enzyme (ACE) inhibitor and the active metabolite of quinapril. Quinapril specifically blocks the conversion of angiotensin I to the vasoc
MDL NumberMFCD00865778
SMILESN2([C@@H](Cc3c(cccc3)C2)C(=O)O)C(=O)[C@@H](N[C@@H](CCc1ccccc1)C(=O)O)C
InChI1S/C23H26N2O5/c1-15(24-19(22(27)28)12-11-16-7-3-2-4-8-16)21(26)25-14-18-10-6-5-9-17(18)13-20(25)23(29)30/h2-10,15,19-20,24H,11-14H2,1H3,(H,27,28)(H,29,30)/t15-,19-,20-/m0/s1
InChI KeyFLSLEGPOVLMJMN-YSSFQJQWSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/61518_1_82768_85_2.pdf
BioactivityQuinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) In Vitro Quinaprilat (5 μM) mediates the interaction of organic anion transporter 3 (hOAT3) which can promote renal active secretion of quinapril that increases uptake of quinaprilat to 25-fold in HEK293 cells and hOAT3 affinity Km for quinaprilat is 13.4 μM[1]. Quinaprilat (100 nM, 20 min) can inhibit the activity of protein kinase C (PKC) by activing the B1 receptor resulting in the release of NO in human lung microvascular endothelial (HLMVE) cells[2]. References [1]. Haodan Yuan, et al. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. J Pharmacol Exp Ther. 2009 Jul;330(1):191-7. doi: 10.1124/jpet.108.149476. Epub 2009 Apr 6. [2]. Sinisa Stanisavljevic, et al. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. J Pharmacol Exp Ther. 2006 Mar;316(3):1153-8. Chemical & Physical Properties Density 1.289 g/cm3 Boiling Point 674.5ºC at 760 mmHg Melting Point 166-168ºC Molecular Formula C23H26N2O5 Molecular Weight 410.46300 Flash Point 361.7ºC Exact Mass 410.18400 PSA 106.94000 LogP 2.41740 InChIKey FLSLEGPOVLMJMN-YSSFQJQWSA-N SMILES CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1Cc2ccccc2CC1C(=O)O
Use ofQuinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator[1][2]. Properties Name quinaprilat hydrate Synonym More Synonyms CI928 Biological Activity Description Quinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) References [2]. Sinisa Stanisavljevic, et al. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. J Pharmacol Exp Ther. 2006 Mar;316(3):1153-8. Chemical & Physical Properties Molecular Formula C23H26N2O5 Exact Mass 410.18400 PSA 106.94000 LogP 2.41740 InChIKey FLSLEGPOVLMJMN-YSSFQJQWSA-N
Transport InfoProduct Name: Quinapril
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