CAS Number85-87-0
Synonyms2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine; 4-Aminomethyl-5-hydroxy-6-methyl-3-pyridinemethanol; pyridoxiamine; PyridoxaMine-d4; pyridoxylamine; Pyridorin
Molecular FormulaC8H12O2N2
Molecular Weight168.2
Purity98%
Density1.282g/cm3
Boiling Point460.1ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85-87-0 |
| Catalog No. | 2A-9061338 |
| Chinese Name | 吡多胺 |
| Synonyms | 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine; 4-Aminomethyl-5-hydroxy-6-methyl-3-pyridinemethanol; pyridoxiamine; PyridoxaMine-d4; pyridoxylamine; Pyridorin |
| Molecular Formula | C8H12O2N2 |
| Molecular Weight | 168.2 |
| Purity | 98 |
| Density | 1.282g/cm3 |
| Boiling Point | 460.1ºC at 760 mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | Pyridoxylamine is an inhibitor of glycation end products (AGE) and lipidation end products (ALE) and protects against diabetes-induced retinal vasculopathy. |
| HTC | 2933399090 |
| MDL Number | MFCD00464815 |
| SMILES | Cc1ncc(CO)c(CN)c1O |
| InChI | InChI=1S/C8H12N2O2/c1-5-8(12)7(2-9)6(4-11)3-10-5/h3,11-12H,2,4,9H2,1H3 |
| InChI Key | NHZMQXZHNVQTQA-UHFFFAOYSA-N |
| MSDS | msds/61338_1_85_87_0.pdf |
| Use of | Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. Properties Name pyridoxamine Synonym More Synonyms Pyridoxylamine Biological Activity Description Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions. Related Catalog Research Areas >> Metabolic Disease Natural Products >> Others Human Endogenous Metabolite In Vitro Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1]. In Vivo Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo[1]. References [1]. Stitt A, et al. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes. 2002 Sep;51(9):2826-32. Chemical & Physical Properties Molecular Formula C8H12N2O2 Exact Mass 168.09000 PSA 79.37000 LogP 0.74690 Index of Refraction 1.617 InChIKey NHZMQXZHNVQTQA-UHFFFAOYSA-N SMILES Cc1ncc(CO)c(CN)c1O Safety Information HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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