CAS Number66508-37-0
SynonymsSodium hydrogen [(2S,3R)-3-methyl-2-oxiranyl]phosphonate; sodium,3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate; Phosphonic acid, [(2S,3R)-3-methyloxiranyl]-, sodium salt (1:1)
Molecular FormulaC4H9NNaO5P
Molecular Weight205.08
Purity98%
Boiling Point463.7ºC at 760 mmHg
Melting Point189-191ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 66508-37-0 |
| Catalog No. | 2A-9060863 |
| Chinese Name | 膦胺霉素钠盐 |
| Synonyms | Sodium hydrogen [(2S,3R)-3-methyl-2-oxiranyl]phosphonate; sodium,3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate; Phosphonic acid, [(2S,3R)-3-methyloxiranyl]-, sodium salt (1:1) |
| Molecular Formula | C4H9NNaO5P |
| Molecular Weight | 205.08 |
| Purity | 98 |
| Boiling Point | 463.7ºC at 760 mmHg |
| Melting Point | 189-191ºC |
| Storage Condition | -20°C |
| Application | Fosmidomycin sodium salt is a phosphate antibiotic and antimalarial drug active against both Gram-negative and Gram-positive bacteria. |
| HTC | 2931900090 |
| MDL Number | C4H9NNaO5P |
| SMILES | O=CN(O)CCCP(=O)([O-])O.[Na+] |
| InChI Key | ZZPUYRHMTGOTEU-UHFFFAOYSA-M |
| MSDS | msds/60863_1_66508_37_0.pdf |
| Use of | Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria. Properties Name Fosmidomycin Sodium Salt Synonym More Synonyms Fosmidomycin sodium salt Biological Activity Description Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro Fosmidomycin sodium salt is a phosphonic acid antibiotic[1][2], which is active against both Gram-negative and Gram-positive bacteria[3]. References [1]. Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8. [2]. Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90. [3]. Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6. Chemical & Physical Properties Molecular Formula C4H9NNaO5P PSA 82.70000 LogP 0.34710 InChIKey ZZPUYRHMTGOTEU-UHFFFAOYSA-M SMILES O=CN(O)CCCP(=O)([O-])O.[Na+] Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt CAS REGISTRY NUMBER : 66508-37-0 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C4-H9-N-O5-P.Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 19(5),668,1985 Safety Information HS Code 2931900090 Synthetic Route dibenzyl (3-(N-... CAS#:1417822-59-3 Fosmidomycin so... CAS#:66508-37-0 Literature: Suresh, Surisetti; Shyamraj, Dharavath; Larhed, Mats Tetrahedron, 2013 , vol. 69, # 3 p. 1183 - 1188 Formic Acid CAS#:64-18-6 3-( Hydroxyamin... CAS#:66508-11-0 Fosmidomycin so... CAS#:66508-37-0 Literature: US6680308 B1, ; Page column 15, 16 ; 3-( Hydroxyamin... CAS#:66508-11-0 5-methyl-2-sulf... CAS#:100747-87-3 Fosmidomycin so... CAS#:66508-37-0 Literature: Yazawa, Hisatoyo; Goto, Shunsuke Tetrahedron Letters, 1985 , vol. 26, # 31 p. 3703 - 3706 Precursor & DownStream Precursor 5 CAS#:64-18-6 Formic Acid CAS#:66508-11-0 3-( Hydroxyamin... CAS#:100747-87-3 5-methyl-2-sulf... CAS#:2258-42-6 Formyl acetate DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | AB (Inbound cargo customs clearance form) |
| Transport Info | Product name: Fosfomycin sodium salt |
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