CAS Number154992-24-2
SynonymsRu-58841; 4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxy-butyl)-1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile; 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile; T5NVNV EHJ A4Q CR DCN CXFFF& E1 E1; 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; RU58841; RU 58841
Molecular FormulaC17H18O3N3F3
Molecular Weight369.34
Purity98%
Density1.4±0.1 g/cm3
Boiling Point493.6±55.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 154992-24-2 |
| Catalog No. | 2A-9061086 |
| Chinese Name | 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈 |
| Synonyms | Ru-58841; 4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxy-butyl)-1-imidazolidinyl)-2-(trifluoromethyl)-benzonitrile; 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile; T5NVNV EHJ A4Q CR DCN CXFFF& E1 E1; 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; RU58841; RU 58841 |
| Molecular Formula | C17H18O3N3F3 |
| Molecular Weight | 369.34 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 493.6±55.0 °C at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | RU 58841 (PSK-3841) is an androgen receptor antagonist that promotes hair regrowth. |
| HTC | 2933990090 |
| MDL Number | MFCD00925776 |
| SMILES | CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1CCCCO |
| InChI | InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3 |
| InChI Key | ARBYGDBJECGMGA-UHFFFAOYSA-N |
| MSDS | msds/61086_1_154992_24_2.pdf |
| Use of | RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen. RU 58841 (PSK-3841) has a dramatic effect on hair regrowth. Properties Name 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile Synonym More Synonyms RU58841 Biological Activity Description RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen. RU 58841 (PSK-3841) has a dramatic effect on hair regrowth. Related Catalog Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Endocrinology Androgen receptor References [1]. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice By De Brouwer, B.; Tetelin, C.; Leroy, T.; Bonfils, A.; Van Neste, D. .From British Journal of Dermatology (1997), 137(5), 699-702. [2]. Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Sch?fer-Korting M.RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia.Pharmazie. 2005 Jan;60(1):8-12. [3]. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D.RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60. [4]. Blaschke T, Kankate L, Kramer KD.Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy.Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. Epub 2007 May 3. [5]. Matias JR, Gaillard M.Local inhibition of sebaceous gland growth by topically applied RU 58841.Ann N Y Acad Sci. 1995 Jun 12;761:56-65. Chemical & Physical Properties Molecular Formula C17H18F3N3O3 Exact Mass 369.130035 PSA 84.64000 Index of Refraction 1.560 InChIKey ARBYGDBJECGMGA-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route Total: 1 Page 4-Bromobutyl acetate CAS#:4753-59-7 4-(4,4-Dimethyl... CAS#:143782-20-1 CAS#:154992-24-2 Literature: Leonard, Matthew J.; Lingham, Anthony R.; Niere, Julie O.; Jackson, Neale R. C.; McKay, Peter G.; Huegel, Helmut M. RSC Advances, 2014 , vol. 4, # 27 p. 14143 - 14148 4-Amino-2-(trif... CAS#:654-70-6 CAS#:154992-24-2 Literature: RSC Advances, , vol. 4, # 27 p. 14143 - 14148 p-cyano-m-trifl... CAS#:1259327-69-9 CAS#:154992-24-2 Literature: RSC Advances, , vol. 4, # 27 p. 14143 - 14148 Precursor & DownStream Precursor 3 CAS#:4753-59-7 4-Bromobutyl acetate CAS#:143782-20-1 4-(4,4-Dimethyl... CAS#:654-70-6 4-Amino-2-(trif... DownStream 1 CAS#:4427-97-8 dicyclohexyl ca... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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