CAS Number1476-52-4
Synonyms4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine; 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline,Monodesethylchloroquine
Molecular FormulaC16H22ClN3
Molecular Weight291.82
Purity98%%
Density1.138g/cm3
Boiling Point343.4-347 °F (173-175°C; 845.06°F )
Melting Point176-215.6 °F (80-102°C)
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1476-52-4 |
| Catalog No. | 2A-9061004 |
| Chinese Name | 去乙基氯喹 |
| Synonyms | 4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine; 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline,Monodesethylchloroquine |
| Molecular Formula | C16H22ClN3 |
| Molecular Weight | 291.82 |
| Purity | 98% |
| Density | 1.138g/cm3 |
| Boiling Point | 343.4-347 °F (173-175°C; 845.06°F ) |
| Melting Point | 176-215.6 °F (80-102°C) |
| Appearance | powder |
| Storage Condition | -20°C Freezer |
| Application | Desethyl chloroquine is the major deethylated metabolite of Chloroquine. Chloroquine is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine has anti-Plasmodium activity. |
| HTC | 2933499090 |
| MDL Number | MFCD00871808 |
| SMILES | ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
| InChI | 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) |
| InChI Key | MCYUUUTUAAGOOT-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/61004_1_1476_52_4.pdf |
| Use of | Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2]. Properties Name Desethyl Chloroquine Synonym More Synonyms Desethyl Chloroquine Biological Activity Description Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy In Vitro P. falciparum[1] References [1]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. [2]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [3]. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74. Chemical & Physical Properties Exact Mass 291.15000 PSA 36.95000 LogP 4.54220 Index of Refraction 1.602 InChIKey MCYUUUTUAAGOOT-UHFFFAOYSA-N Safety Information RIDADR NONH for all modes of transport HS Code 2933499090 Synthetic Route Total: 1 Page Ethylamine CAS#:75-04-7 Desethyl Chloroquine CAS#:1476-52-4 Literature: Journal of the American Chemical Society, , vol. 68, p. 1224 Chloroquine CAS#:54-05-7 Desethyl Chloroquine CAS#:1476-52-4 Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442 4,7-Dichloroqui... CAS#:86-98-6 Desethyl Chloroquine CAS#:1476-52-4 Literature: Journal of the American Chemical Society, , vol. 68, p. 1224 Precursor & DownStream Precursor 3 CAS#:75-04-7 Ethylamine CAS#:54-05-7 Chloroquine CAS#:86-98-6 4,7-Dichloroqui... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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