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Galanthamine Hydrobromide

Name: Galanthamine Hydrobromide
Brand: 2A Biotech
SKU: 2A-9060537

CAS Number1953-04-4

SynonymsNIVALIN,HBR; MFCD00067672; Galanthamine hydrobromide (1:1); GALANTHAMIDE HYDROBROMIDE; [3H]-Galantamine hydrobromide; UNII:5N4SA4KQX9; galanthamine bromhydrate (1:1); Galantamine hydrobromide (JAN/USAN); Galanthamine HBr; Galanthamine (hydrobromide); Galantamine hydrobromide; (-)-Galanthaminium bromide; NIVALIN; galanthaminhydrobromid(1:1); GALANTHAMINE HYDROBROMIDUM; EINECS 217-780-5; GALANTAMINE HBR

Molecular FormulaC17H22BrNO3

Molecular Weight287.35 (free base basis)

Purity≥95 (HPLC)%

Melting Point256 °C

Appearancesolid

MSDSChinese English

Cat. No.: 2A-9060537 Purity: ≥95 (HPLC)%

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Quality Control of [ 1953-04-4 ] Purity: ≥95 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	1953-04-4
Catalog No.	2A-9060537
Chinese Name	氢溴酸加兰他敏
Synonyms	NIVALIN,HBR; MFCD00067672; Galanthamine hydrobromide (1:1); GALANTHAMIDE HYDROBROMIDE; [3H]-Galantamine hydrobromide; UNII:5N4SA4KQX9; galanthamine bromhydrate (1:1); Galantamine hydrobromide (JAN/USAN); Galanthamine HBr; Galanthamine (hydrobromide); Galantamine hydrobromide; (-)-Galanthaminium bromide; NIVALIN; galanthaminhydrobromid(1:1); GALANTHAMINE HYDROBROMIDUM; EINECS 217-780-5; GALANTAMINE HBR
Molecular Formula	C17H22BrNO3
Molecular Weight	287.35 (free base basis)
Purity	≥95 (HPLC)
Melting Point	256 °C
Appearance	solid
Storage Condition	Sealed, store at -20 ºC
Packaging	III
Application	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase (AChE) inhibitor with an IC50 of 410 nM. It is also an allosteric enhancer of neuronal nicotinic acetylcholine recepto
MDL Number	MFCD05734759
SMILES	[Br-].[N+H]1(CC[C@@]32[C@@H](Oc4c3c(ccc4OC)C1)C[C@H](C=C2)O)C
InChI	1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChI Key	QORVDGQLPPAFRS-XPSHAMGMSA-N
NACRES Code	NA.77
UNSPSC	12352116
MSDS	msds/60537_1_1953_04_4.pdf
Bioactivity	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease References [1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30. [2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73. [3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5. [4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28. [5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103. Chemical & Physical Properties Melting Point 256 °C Molecular Formula C17H22BrNO3 Molecular Weight 368.266 Exact Mass 367.078308 PSA 41.93000 LogP 2.74630 Vapour Pressure 0mmHg at 25°C Index of Refraction -95 ° (C=1.4, H2O) InChIKey QORVDGQLPPAFRS-XPSHAMGMSA-N SMILES Br.COc1ccc2c3c1OC1CC(O)C=CC31CCN(C)C2 Storage condition −20°C
Use of	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease. Properties Articles40 Name Galanthamine hydrobromide Synonym More Synonyms Galantamine hydrobromide Biological Activity Description Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease References [1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30. [2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73. [3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5. [4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28. [5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103. Chemical & Physical Properties Molecular Formula C17H22BrNO3 Exact Mass 367.078308 PSA 41.93000 LogP 2.74630 InChIKey QORVDGQLPPAFRS-XPSHAMGMSA-N
Transport Info	Product name: Purity: 99.0%
MSDS Transport Info	Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III

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Galanthamine Hydrobromide

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