CAS Number4419-39-0
SynonymsBeclometasone; Beclomethasone; EINECS 224-585-9; MFCD00135614; beclometasone 17,21-dipropionate; 9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate
Molecular FormulaC22H29ClO5
Molecular Weight521.042
Purity98%
Density1.3±0.1 g/cm3
Boiling Point630.5±55.0 °C at 760 mmHg
Melting Point210ºC
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4419-39-0 |
| Catalog No. | 2A-9060408 |
| Chinese Name | 倍氯米松 |
| Synonyms | Beclometasone; Beclomethasone; EINECS 224-585-9; MFCD00135614; beclometasone 17,21-dipropionate; 9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate |
| Molecular Formula | C22H29ClO5 |
| Molecular Weight | 521.042 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 630.5±55.0 °C at 760 mmHg |
| Melting Point | 210ºC |
| Appearance | White to off-white crystalline powder |
| Storage Condition | 2-8°C |
| Application | Beclometasone (Beclomethasone) is a glucocorticoid receptor agonist. |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1(O)C(=O)CO |
| InChI | InChI=1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 |
| InChI Key | NBMKJKDGKREAPL-DVTGEIKXSA-N |
| MSDS | msds/60408_1_4419_39_0.pdf |
| Bioactivity | Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Target Glucocorticoid Receptor[1] In Vitro An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation[1]. Cell Assay The transgenic lines Tg(fli1:GFP) and Tg(mpx:GFP) are used in this study. 0.2 mM N-phenylthiourea (PTU) is applied to prevent pigment formation from 1 day post-fertilization (dpf). For Pu.1 knockdown, Pu.1 MO (1 mM for partial knockdown and 2 mM for complete knockdown is injected into the yolk at the one-cell stage. For pharmacological inhibition, the VEGFR tyrosine kinase inhibitors KRN633 (0.1-1 μM) or Sunitinib (0.1-1 μM), Beclomethasone (25 μM) and β-amino-proprionitrile (βAPN, 500 μM) are applied directly to the egg water and refreshed every 2 days. For pharmacological inhibition, Beclomethasone is applied to the embryos 4 h before implantation and KRN633, Sunitinib and βAPN are applied 4-6 h post-implantation. For each cell line or condition, data are representative of ≥ three independent experiments, with ≥30 embryos/group. Experiments are discarded when the survival rate of the control group is <90%[1]. References [1]. He S, et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol. 2012 Aug;227(4):431-45. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 630.5±55.0 °C at 760 mmHg Melting Point 210ºC Molecular Formula C22H29ClO5 Molecular Weight 521.042 Flash Point 335.1±31.5 °C Exact Mass 520.222778 PSA 94.83000 LogP 4.59 Vapour Pressure 0.0±4.2 mmHg at 25°C Index of Refraction 1.564 InChIKey NBMKJKDGKREAPL-DVTGEIKXSA-N SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1(O)C(=O)CO Storage condition 2-8°C |
| Use of | Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist. Properties Articles56 Name beclomethasone Synonym More Synonyms Beclometasone Biological Activity Description Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Glucocorticoid Receptor[1] In Vitro An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation[1]. References [1]. He S, et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol. 2012 Aug;227(4):431-45. Chemical & Physical Properties Exact Mass 520.222778 PSA 94.83000 Index of Refraction 1.564 InChIKey NBMKJKDGKREAPL-DVTGEIKXSA-N |
| Transport Info | Product name: Beclomethasone solution standard material in methanol |
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