| Chemical & Physical Properties | |
|---|---|
| CAS Number | 152459-95-5 |
| Catalog No. | 2A-9060355 |
| Chinese Name | 伊马替尼 |
| Synonyms | Imatinib; STI571; Imatinib (STI571); 1iep; MFCD05662257; Imatinib free base; 1xbb |
| Molecular Formula | C29H31N7O |
| Molecular Weight | 493.60 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 451°C |
| Melting Point | 113°C |
| Appearance | solid |
| Storage Condition | Refrigerator |
| Packaging | II |
| Application | Imatinib is a tyrosine kinase inhibitor that inhibits c-Kit, Bcr-Abl and PDGFR. |
| HTC | 2933990090 |
| PubChem ID | 329795436 |
| MDL Number | MFCD05662257 |
| SMILES | O=C(C(C=C1)=CC=C1CN2CCN(C)CC2)NC3=CC(NC4=NC(C5=CN=CC=C5)=CC=N4)=C(C)C=C3 |
| InChI | 1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) |
| InChI Key | KTUFNOKKBVMGRW-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1 |
| MSDS | msds/60355_1_152459_95_5.pdf |
| Use of | Imatinib is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases. Properties Name imatinib Synonym More Synonyms Imatinib (STI571) Biological Activity Description Imatinib is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Research Areas >> Cancer PDGFR:100 nM (IC50) c-Kit:100 nM (IC50) References [1]. Heinrich MC, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 Aug 1;96(3):925-32. [2]. Guida T, et al. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1;13(11):3363-9. [3]. Okuda K, et al. ARG tyrosine kinase activity is inhibited by STI571.Blood. 2001 Apr 15;97(8):2440-8 [4]. Yao JC, et al. Clinical and in vitro studies of imatinib in advanced carcinoid tumors. Clin Cancer Res. 2007 Jan 1;13(1):234-40. [5]. Sun XC, et al. Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice. World J Gastroenterol. 2013 Apr 21;19(15):2340-7. [6]. Yildiz C, et al. Effect of imatinib on growth of experimental endometriosis in rats. Eur J Obstet Gynecol Reprod Biol. 2016 Feb;197:159-63. Chemical & Physical Properties Molecular Formula C29H31N7O Exact Mass 493.259003 PSA 86.28000 Index of Refraction 1.672 InChIKey KTUFNOKKBVMGRW-UHFFFAOYSA-N Storage condition Refrigerator Safety Information Hazard Codes T,N WGK Germany 3 Packaging Group II Hazard Class 6.1 HS Code 2933990090 Synthetic Route N-(5-Amino-2-me... 152460-10-1 4-(4-Methylpipe... 148077-69-4 Imatinib (STI57... 152459-95-5 Literature: CHEMAGIS LTD. Patent: EP1857454 A1, 2007 ; Location in patent: Page/Page column 4 ; N-(5-Amino-2-me... 152460-10-1 Methyl 4-[(4-me... 314268-40-1 Imatinib (STI57... 152459-95-5 4-(4-methyl pip... 1044872-32-3 N-(5-Amino-2-me... 152460-10-1 Imatinib (STI57... 152459-95-5 Precursor & DownStream Precursor 7 CAS#:152460-10-1 N-(5-Amino-2-me... CAS#:148077-69-4 4-(4-Methylpipe... CAS#:314268-40-1 Methyl 4-[(4-me... CAS#:1044872-32-3 4-(4-methyl pip... DownStream 2 CAS#:571186-91-9 Imatinib (Piper... CAS#:571186-93-1 iMatinib relate... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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