CAS Number161832-65-1
SynonymsKinampa; Talampanel; (R)-7-acetyl-5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; Ampanel; (R)-(-)-1-(4-aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine; (R)-7-Acetyl-5-(p-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; Talampanel (INN); (R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzo-diazepine
Molecular FormulaC19H19N3O3
Molecular Weight337.37
Purity≥97 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point528.9±60.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 161832-65-1 |
| Catalog No. | 2A-9060295 |
| Chinese Name | (8R)-7-乙酰基-5-(4-氨基苯基)-8,9-二氢-8-甲基-7H-1,3-二氧杂环戊烯并[4,5-H][2,3]苯并二氮杂卓 |
| Synonyms | Kinampa; Talampanel; (R)-7-acetyl-5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; Ampanel; (R)-(-)-1-(4-aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine; (R)-7-Acetyl-5-(p-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine; Talampanel (INN); (R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzo-diazepine |
| Molecular Formula | C19H19N3O3 |
| Molecular Weight | 337.37 |
| Purity | ≥97 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 528.9±60.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | Talampanel is a potent and selective AMPA receptor antagonist and a potential new antiepileptic drug (AED). |
| PubChem ID | 329825584 |
| MDL Number | MFCD00871406 |
| SMILES | C[C@H](C1)N(C(C)=O)N=C(C2=CC=C(N)C=C2)C3=C1C=C(OCO4)C4=C3 |
| InChI | 1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1 |
| InChI Key | JACAAXNEHGBPOQ-LLVKDONJSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/60295_1_161832_65_1.pdf |
| Bioactivity | Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Target: AMPA [1]in vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.in vivo： Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2] Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Langan YM, et al. Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia. 2003 Jan;44(1):46-53. [2]. Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12(5):340-344. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 528.9±60.0 °C at 760 mmHg Molecular Formula C19H19N3O3 Molecular Weight 337.372 Flash Point 273.7±32.9 °C Exact Mass 337.142639 PSA 77.15000 LogP 1.23 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.675 InChIKey JACAAXNEHGBPOQ-LLVKDONJSA-N SMILES CC(=O)N1N=C(c2ccc(N)cc2)c2cc3c(cc2CC1C)OCO3 Storage condition 2-8℃ |
| Use of | Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Target: AMPA [1]in vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.in vivo： Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2] Properties Name 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone Synonym More Synonyms Talampanel Biological Activity Description Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Target: AMPA [1]in vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.in vivo： Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2] Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease References [1]. Langan YM, et al. Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia. 2003 Jan;44(1):46-53. Chemical & Physical Properties Molecular Formula C19H19N3O3 Exact Mass 337.142639 PSA 77.15000 Index of Refraction 1.675 InChIKey JACAAXNEHGBPOQ-LLVKDONJSA-N Storage condition 2-8℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. ((R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8- methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. ((R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8- methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine hydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. ((R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8- methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: No Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users No data available |
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