| Chemical & Physical Properties | |
|---|---|
| CAS Number | 605-62-9 |
| Catalog No. | 2A-9005998 |
| Chinese Name | 4-硝基-1-萘酚 |
| Synonyms | 4-nitronaphthalen-1-ol; MFCD02179392; 4-Nitro-1-naphthol |
| Molecular Formula | C10H7NO3 |
| Molecular Weight | 293.28 |
| Purity | 99 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 398.8±25.0 °C at 760 mmHg |
| Melting Point | 277-280 °C (decomposition) |
| Appearance | solid |
| Storage Condition | Storage: Seal the container and store it in a seal |
| Application | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor with IC50s of 141μM (KAT9), 221μM (KAT2B) and 106μM (KAT3B). KAT8 inhibits histone acetyltransferases (HATs) and may contribute to diseas |
| HTC | 2908999090 |
| MDL Number | MFCD02659296 |
| SMILES | [N+](=O)([O-])c1ccc(cc1)N\N=C2\c3c(cccc3)C(=O)C=C\2 |
| InChI | 1S/C16H11N3O3/c20-16-10-9-15(13-3-1-2-4-14(13)16)18-17-11-5-7-12(8-6-11)19(21)22/h1-10,17H/b18-15+ |
| InChI Key | UYDXOFSMBKSLPM-OBGWFSINSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352104 |
| MSDS | msds/5998_1_605_62_9.pdf |
| Bioactivity | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Target IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B)[1] In Vitro KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1]. References [1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 398.8±25.0 °C at 760 mmHg Melting Point 165-168°C Molecular Formula C10H7NO3 Molecular Weight 189.167 Flash Point 179.8±11.6 °C Exact Mass 189.042587 PSA 66.05000 LogP 2.80 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.714 InChIKey AUIRNGLMBHIITH-UHFFFAOYSA-N SMILES O=[N+]([O-])c1ccc(O)c2ccccc12 |
| Use of | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. Properties Name 4-Nitro-1-naphthol Synonym More Synonyms 4-Nitro-1-naphthol Biological Activity Description KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B)[1] References [1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486. Chemical & Physical Properties Molecular Formula C10H7NO3 Exact Mass 189.042587 PSA 66.05000 Index of Refraction 1.714 InChIKey AUIRNGLMBHIITH-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product Name: Summary 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff:5.5%. General tariff:30.0% |
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