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Amikacin sulfate salt structure, CAS 149022-22-0

Amikacin sulfate salt

CAS Number149022-22-0

SynonymsAMIKACIN SULFATE 1:1.8; amikacin sulphate

Molecular FormulaC22H43N5O13.9/5H2O4S

Molecular Weight781.760

Purity

Density

Boiling Point981.8ºC at 760mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9059760 Purity:
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Quality Control of [ 149022-22-0 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number149022-22-0
Catalog No.2A-9059760
Chinese Name硫酸阿米卡星(5:9)
SynonymsAMIKACIN SULFATE 1:1.8; amikacin sulphate
Molecular FormulaC22H43N5O13.9/5H2O4S
Molecular Weight781.760
Boiling Point981.8ºC at 760mmHg
Appearancepowder
Water SolubilityH2O: soluble50mg/mL
Storage Condition2-8°C
ApplicationAmikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semi-synthetic analog of kanamycin. Amikacin sulfate has a bactericidal effect and acts directly on the 30S and 50S bacteri
HTC2941902000
PubChem ID24890648
MDL NumberMFCD00167477
SMILESOS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
InChI1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
InChI KeyHIBICIOPDUTNRR-BOEHXBESSA-N
NACRES CodeNA.85
UNSPSC41116107
MSDSmsds/59760_1_149022_22_0.pdf
Use ofAmikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2]. Properties Name Amikacin sulfate salt Synonym More Synonyms Amikacin sulfate Biological Activity Description Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi)[1]. Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM[3]. References [1]. Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28. [2]. Ristuccia AM, et al. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25. [3]. Siân R Kitcher, et al. ORC-13661 Protects Sensory Hair Cells From Aminoglycoside and Cisplatin Ototoxicity. JCI Insight. 2019 Aug 8;4(15):e126764. Chemical & Physical Properties Exact Mass 781.220520 PSA 497.90000 Appearance of Characters white to off-white InChIKey HIBICIOPDUTNRR-BOEHXBESSA-N Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR NONH for all modes of transport WGK Germany 2 RTECS WK1961200 HS Code 2941902000
Transport InfoProduct Name: Amikacin Sulfate
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