CAS Number183319-69-9
SynonymsErlotonid HCl; Erlotinib hydrochloride; Erlotinib-d6 HCl; ERLOTINIB HCL SALT; CP-358774-01; Erlotinib Hydrochloride Salt; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1); MFCD07781272; Hydrogen chloride - N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine (1:1:1); Tarceva; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1); N-(3-Ethinylphenyl)-6,7-bis(2-methoxyethoxy)chinazolin-4-aminhydrochlorid; OSI 774; Erlotinib,OS-774; Erlotinib (Hydrochloride); Erlotinib HCl
Molecular FormulaC22H24ClN3O4
Molecular Weight429.90
Boiling Point553.6ºC at 760 mmHg
Melting Point223-225ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 183319-69-9 |
| Catalog No. | 2A-9059637 |
| Chinese Name | 盐酸埃罗替尼 |
| Synonyms | Erlotonid HCl; Erlotinib hydrochloride; Erlotinib-d6 HCl; ERLOTINIB HCL SALT; CP-358774-01; Erlotinib Hydrochloride Salt; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, hydrochloride (1:1); MFCD07781272; Hydrogen chloride - N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine (1:1:1); Tarceva; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride (1:1); N-(3-Ethinylphenyl)-6,7-bis(2-methoxyethoxy)chinazolin-4-aminhydrochlorid; OSI 774; Erlotinib,OS-774; Erlotinib (Hydrochloride); Erlotinib HCl |
| Molecular Formula | C22H24ClN3O4 |
| Molecular Weight | 429.90 |
| Boiling Point | 553.6ºC at 760 mmHg |
| Melting Point | 223-225ºC |
| Appearance | solid |
| Storage Condition | -20°C Freezer |
| Application | Erlotinib inhibits EGFR kinase with an IC50 of 2 nM. |
| HTC | 2933990090 |
| PubChem ID | 329795839 |
| MDL Number | MFCD07781272 |
| SMILES | C#CC1=CC(NC2=NC=NC3=CC(OCCOC)=C(OCCOC)C=C32)=CC=C1.Cl |
| InChI | 1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H |
| InChI Key | GTTBEUCJPZQMDZ-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| MSDS | msds/59637_1_183319_69_9.pdf |
| Use of | Erlotinib hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Properties Name erlotinib hydrochloride Synonym More Synonyms Erlotinib HCl (OSI-744) Biological Activity Description Erlotinib hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Research Areas >> Cancer EGFR:2 nM (IC50) References [1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. [2]. Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. [3]. Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-typ [4]. Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14. Chemical & Physical Properties Exact Mass 429.145538 PSA 74.73000 LogP 4.28010 InChIKey GTTBEUCJPZQMDZ-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 3-Aminophenylac... 54060-30-9 Erlotinib HCl (... 183319-69-9 Literature: Ube Industries, Ltd. Patent: EP1481971 A1, 2004 ; Location in patent: Page 9 ; 183321-74-6 Erlotinib HCl (... 183319-69-9 3-butyn-2-ol, 4... 299912-59-7 Erlotinib HCl (... 183319-69-9 Literature: F.I.S. Fabbrica Italiana Sintetici S.p.A. Patent: EP2433931 A1, 2012 ; Location in patent: Page/Page column 12 ; Precursor & DownStream Precursor 8 CAS#:54060-30-9 3-Aminophenylac... CAS#:183321-74-6 CAS#:299912-59-7 3-butyn-2-ol, 4... CAS#:183322-18-1 4-Chloro-6,7-(2... DownStream 1 CAS#:183321-74-6 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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