| Chemical & Physical Properties | |
|---|---|
| CAS Number | 186097-54-1 |
| Catalog No. | 2A-9059638 |
| Chinese Name | 西洛雷定盐酸盐 |
| Synonyms | DK-AH 269; Cilobradine (hydrochloride) |
| Molecular Formula | C28H39ClN2O5 |
| Molecular Weight | 519.08 |
| Boiling Point | 655.7ºC at 760 mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | Cilobradine is an HCN channel blocker. |
| MDL Number | C28H39ClN2O5 |
| SMILES | COc1ccc(CCN2CCCC(CN3CCc4cc(OC)c(OC)cc4CC3=O)C2)cc1OC.Cl |
| InChI Key | MTAKUIYCCYKGJJ-BOXHHOBZSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/59638_1_186097_54_1.pdf |
| Bioactivity | Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.Target: HCN Channel blockerCilobradine is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of Cilobradine. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine (8 ± 2% inhibition; n = 4). Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> HCN Channel Research Areas >> Cardiovascular Disease References [1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939. Chemical & Physical Properties Boiling Point 655.7ºC at 760 mmHg Molecular Formula C28H39ClN2O5 Molecular Weight 519.07300 Flash Point 350.4ºC Exact Mass 518.25500 PSA 60.47000 LogP 4.28070 Vapour Pressure 1.96E-17mmHg at 25°C InChIKey MTAKUIYCCYKGJJ-BOXHHOBZSA-N SMILES COc1ccc(CCN2CCCC(CN3CCc4cc(OC)c(OC)cc4CC3=O)C2)cc1OC.Cl |
| Use of | Properties Name Cilobradine hydrochloride Synonym More Synonyms DK-AH 269 Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> HCN Channel Research Areas >> Cardiovascular Disease References [1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939. Chemical & Physical Properties Exact Mass 518.25500 PSA 60.47000 LogP 4.28070 InChIKey MTAKUIYCCYKGJJ-BOXHHOBZSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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