![6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline structure, CAS 927691-21-2](/structures/60000/59183_1_927691_21_2.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 927691-21-2 |
| Catalog No. | 2A-9059183 |
| Chinese Name | 6,7-二甲氧基-4-[(3R)-3-(2-喹喔啉基氧基)-1-吡咯烷基]喹唑啉 |
| Synonyms | PQ-10 |
| Molecular Formula | C28H39N5O3 |
| Molecular Weight | 403.43 |
| Purity | ≥98 (HPLC) |
| Density | 1.333 |
| Appearance | powder |
| Storage Condition | -20°C, sealed, dry |
| Application | PQ-10 is a potent inhibitor of phosphodiesterase 10A (PDE10A), with IC50 and D50 of 4.6nm and 13mg/kg respectively. PQ-10 induces brain glucose metabolism patterns, which may be a potential translatio |
| PubChem ID | 329825657 |
| MDL Number | MFCD12828216 |
| SMILES | COC1=CC2=C(N3C[C@H](OC4=CN=C(C=CC=C5)C5=N4)CC3)N=CN=C2C=C1OC |
| InChI | 1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1 |
| InChI Key | UBIIFKJMNRPNMT-CQSZACIVSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 41106305 |
| Hazard Symbols | transportation |
| MSDS | msds/59183_1_927691_21_2.pdf |
| Bioactivity | PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease Target PDE10A:4.6 nM (IC50) In Vivo PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice[1]. Animal Model: 24 -28 g male C57BL/6 mice, PDE10A WT and KO mice[1] Dosage: 0.16, 0.63, 2.5, and 10 mg/kg Administration: s.c. Result: Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice. References [1]. Dedeurwaerdere S, et al. Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker. J Pharmacol Exp Ther. 2011;339(1):210-217. Chemical & Physical Properties Density 1.333 Molecular Formula C28H39N5O3 Molecular Weight 403.43400 Exact Mass 403.16400 PSA 82.49000 LogP 3.31290 InChIKey UBIIFKJMNRPNMT-UHFFFAOYSA-N SMILES COc1cc2ncnc(N3CCC(Oc4cnc5ccccc5n4)C3)c2cc1OC |
| Use of | Properties Name 6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline Synonym More Synonyms PQ-10 Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease PDE10A:4.6 nM (IC50) References [1]. Dedeurwaerdere S, et al. Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker. J Pharmacol Exp Ther. 2011;339(1):210-217. Chemical & Physical Properties Molecular Formula C28H39N5O3 Exact Mass 403.16400 PSA 82.49000 LogP 3.31290 InChIKey UBIIFKJMNRPNMT-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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