![N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide structure, CAS 925434-55-5](/structures/60000/59173_1_925434_55_5.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 925434-55-5 |
| Catalog No. | 2A-9059173 |
| Chinese Name | SRT 1720 |
| Synonyms | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide; SRT 1720 |
| Molecular Formula | C25H23N7OS |
| Molecular Weight | 469.56 |
| Purity | ≥97 (HPLC) |
| Density | 1.46 |
| Melting Point | 221ºC |
| Appearance | solid |
| Storage Condition | -20°C, sealed, dry |
| Application | SRT 1720 is a potent activator of human SIRT1 with an EC1.5 value of 0.16 μM and a simultaneous inhibitor of SIRT2 and SIRT3 with EC1.5 values of 37 μM and >300 μM, respectively. |
| HTC | 2934100090 |
| MDL Number | MFCD14584468 |
| SMILES | O=C(C1=NC(C=CC=C2)=C2N=C1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCNCC6)=N4 |
| InChI | 1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33) |
| InChI Key | IASPBORHOMBZMY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/59173_1_925434_55_5.pdf |
| Use of | SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively. Properties Name N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide Synonym More Synonyms SRT 1720 Biological Activity Description SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively. Related Catalog Research Areas >> Metabolic Disease SIRT1:0.16 μM (EC1.5) SIRT2:37 μM (EC1.5) In Vitro SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300[2]. References [1]. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 [2]. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 [3]. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. [4]. Yu L, et al. Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11. Chemical & Physical Properties Molecular Formula C25H23N7OS Exact Mass 469.16800 PSA 115.69000 LogP 4.00320 InChIKey IASPBORHOMBZMY-UHFFFAOYSA-N Safety Information HS Code 2934100090 Synthetic Route Total: 1 Page TERT-BUTYL 4-((... CAS#:925436-46-0 CAS#:925434-55-5 N-(2-(3-(pipera... CAS#:1093403-41-8 CAS#:925434-55-5 Literature: Journal of Medicinal Chemistry, , vol. 52, # 5 p. 1275 - 1283 Precursor & DownStream Precursor 2 CAS#:925436-46-0 TERT-BUTYL 4-((... CAS#:1093403-41-8 N-(2-(3-(pipera... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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