CAS Number651042-82-9
SynonymsO-(2-Mercaptoethyl)-O inverted exclamation marka-methyl-hexa(ethylene glycol); AmbotzPEG1167; mPEG thiol; 2,5,8,11,14,17,20-HEPTAOXADOCOSANE-22-THIOL; O-(2-Mercaptoethyl)-O'-methyl-hexa(ethylene glycol)
Molecular FormulaC15H32O7S
Molecular Weight356.48
Purity≥95 (oligomer purity)%
Density1.065
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 651042-82-9 |
| Catalog No. | 2A-9057795 |
| Chinese Name | 2,5,8,11,14,17,20-七氧杂二十二烷-22-硫醇 |
| Synonyms | O-(2-Mercaptoethyl)-O inverted exclamation marka-methyl-hexa(ethylene glycol); AmbotzPEG1167; mPEG thiol; 2,5,8,11,14,17,20-HEPTAOXADOCOSANE-22-THIOL; O-(2-Mercaptoethyl)-O'-methyl-hexa(ethylene glycol) |
| Molecular Formula | C15H32O7S |
| Molecular Weight | 356.48 |
| Purity | ≥95 (oligomer purity) |
| Density | 1.065 |
| Storage Condition | -20°C |
| Application | m-PEG7-thiol is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 24885119 |
| MDL Number | MFCD08274612 |
| SMILES | COCCOCCOCCOCCOCCOCCOCCS |
| InChI | 1S/C15H32O7S/c1-16-2-3-17-4-5-18-6-7-19-8-9-20-10-11-21-12-13-22-14-15-23/h23H,2-15H2,1H3 |
| InChI Key | PVSKDHZQTUFAEZ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/57795_1_651042_82_9.pdf |
| Bioactivity | m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Density 1.065 Molecular Formula C15H32O7S Molecular Weight 356.47500 Exact Mass 356.18700 PSA 103.41000 LogP 0.66220 InChIKey PVSKDHZQTUFAEZ-UHFFFAOYSA-N SMILES COCCOCCOCCOCCOCCOCCOCCS Storage condition -20°C |
| Use of | m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol Synonym More Synonyms m-PEG7-thiol Biological Activity Description m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C15H32O7S Exact Mass 356.18700 PSA 103.41000 LogP 0.66220 InChIKey PVSKDHZQTUFAEZ-UHFFFAOYSA-N SMILES COCCOCCOCCOCCOCCOCCOCCS |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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