| Chemical & Physical Properties | |
|---|---|
| CAS Number | 649735-46-6 |
| Catalog No. | 2A-9057792 |
| Chinese Name | 布立尼布 |
| Synonyms | Brivanib; bms-540215 |
| Molecular Formula | C19H19FN4O3 |
| Molecular Weight | 370.38 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Appearance | powder |
| Storage Condition | room temperature |
| Application | Brivanib is an ATP-competitive VEGFR2 inhibitor with an IC50 value of 25 nM; it can moderately inhibit VEGFR-1 and FGFR-1, and its selectivity for VEGFR2 is 240 times higher than that for PDGFR-β. |
| HTC | 2933990090 |
| MDL Number | MFCD13194684 |
| SMILES | Fc1c2c([nH]c(c2)C)ccc1Oc3ncn[n]4c3c(c(c4)OC[C@H](O)C)C |
| InChI | 1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 |
| InChI Key | WCWUXEGQKLTGDX-LLVKDONJSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352200 |
| MSDS | msds/57792_1_649735_46_6.pdf |
| Use of | Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Properties Name (2R)-1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol Synonym More Synonyms Brivanib (BMS-540215) Biological Activity Description Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer VEGFR2:25 nM (IC50) References [1]. Bhide RS, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem, 2006, 49 (7), 2143-2146. [2]. Huynh H, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res, 2008, [3]. Nakamura I, et al. Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling. PLoS One. 2015 Nov 3;10(11):e0142355. Chemical & Physical Properties Molecular Formula C19H19FN4O3 Exact Mass 370.144104 PSA 84.67000 Index of Refraction 1.661 InChIKey WCWUXEGQKLTGDX-LLVKDONJSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 4-[(4-fluoro-2-... CAS#:649735-41-1 (R)-(+)-Propyle... CAS#:15448-47-2 Brivanib (BMS-5... CAS#:649735-46-6 Literature: Journal of Medicinal Chemistry, , vol. 51, # 6 p. 1976 - 1980 4-Fluoro-5-hydr... CAS#:288385-88-6 Brivanib (BMS-5... CAS#:649735-46-6 Literature: Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2143 - 2146 5-methyl-4-phen... CAS#:310444-84-9 Brivanib (BMS-5... CAS#:649735-46-6 Literature: Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2143 - 2146 Precursor & DownStream Precursor 8 CAS#:649735-41-1 4-[(4-fluoro-2-... CAS#:15448-47-2 (R)-(+)-Propyle... CAS#:288385-88-6 4-Fluoro-5-hydr... CAS#:310444-84-9 5-methyl-4-phen... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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