EN
0
Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine structure, CAS 475110-96-4

2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine

CAS Number475110-96-4

Synonyms2wxl; ZSTK474; 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole; ZSTK-474,ZST K474; ZSTK-474; TCMDC-137004; S1072_Selleck; 2-(Difluoromethyl)-1-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]-1H-benzimidazole; 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine

Molecular FormulaC19H21F2N7O2

Molecular Weight417.41

Purity≥98 (HPLC)%

Density1.6±0.1 g/cm3

Boiling Point640.3±65.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9057339 Purity: ≥98 (HPLC)%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 475110-96-4 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number475110-96-4
Catalog No.2A-9057339
Chinese NameZSTK474
Synonyms2wxl; ZSTK474; 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole; ZSTK-474,ZST K474; ZSTK-474; TCMDC-137004; S1072_Selleck; 2-(Difluoromethyl)-1-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]-1H-benzimidazole; 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
Molecular FormulaC19H21F2N7O2
Molecular Weight417.41
Purity≥98 (HPLC)
Density1.6±0.1 g/cm3
Boiling Point640.3±65.0 °C at 760 mmHg
Appearancepowder
Storage Condition-20°C
ApplicationZSTK474 is an ATP-competitive pan-class I PI3K inhibitor that inhibits P13Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 16 nM, 44 nM, 4.6 nM and 49 nM respectively.
HTC2934999090
SMILESFC(F)c1[n](c5c(n1)cccc5)c2nc(nc(n2)N4CCOCC4)N3CCOCC3
InChI1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
InChI KeyHGVNLRPZOWWDKD-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/57339_1_475110_96_4.pdf
Use ofZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. Properties Name 4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine Synonym More Synonyms ZSTK474 Biological Activity Description ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer PI3Kα:16 nM (IC50) PI3Kβ:44 nM (IC50) PI3Kδ:4.6 nM (IC50) PI3Kγ:49 nM (IC50) In Vitro Lineweaver-Burk plot analysis revealed that ZSTK474 inhibits all four PI3K isoforms in an ATP-competitive manner. The Ki values determined for the four PI3K isoforms showed that ZSTK474 inhibited the PI3Kδ isoform most effectively with a Ki of 1.8 nM, whereas the other isoforms are inhibited with 4-10-fold higher Ki values. Therefore, ZSTK474 should be regarded as a pan-PI3K inhibitor. We also determined the IC50 values for inhibiting the four PI3K isoforms with ZSTK474 and LY294002. The IC50 values of ZSTK474 (16, 44, 4.6 and 49 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively) are shown to be consistent with the Ki values (6.7, 10.4, 1.8 and 11.7 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively), which further supported the idea that ZSTK474 inhibits PI3Kδ most potently. Even at a concentration of 100 µM, ZSTK474 inhibits mTOR activity rather weakly[1]. References [1]. Kong D, et al. ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci, 2007, 98(10), 1638-1642. Chemical & Physical Properties Molecular Formula C19H21F2N7O2 Exact Mass 417.172485 PSA 81.43000 LogP -0.21 Index of Refraction 1.711 InChIKey HGVNLRPZOWWDKD-UHFFFAOYSA-N Safety Information HS Code 2934999090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Related Products in Heterocyclic Building Blocks
tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate473923-56-72A-9057324
Pyrazolo[1,5-a]pyridine-7-carboxylic acid474432-62-72A-9057328
6-Bromo-4-quinazolinecarboxylic acid ammonium salt474710-80-02A-9057332
3-Aminomethylmorpholine-4-carboxylic acid tert-butyl ester475106-18-42A-9057337
N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea475108-18-02A-9057338
4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine475111-38-72A-9057340
2,3-Dihydro-5-mercapto-3-oxo-4-isothiazolecarboxylic acid sodium salt (1:1)475112-25-52A-9057341
Spiro[furo[3,4-c]pyridine-3(1H),4'-piperidin]-1-one hydrochloride475152-16-02A-9057342
Spiro[furo[3,4-b]pyridine-5(7H),4'-piperidin]-7-one hydrochloride475152-31-92A-9057344
Spiro[furo[3,4-c]pyridine-1(3H),4'-piperidin]-3-one hydrochloride475152-33-12A-9057345
Browse all Heterocyclic Building Blocks products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA