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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea
N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea structure, CAS 475108-18-0

N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea

CAS Number475108-18-0

SynonymsAV951; AV-951; N-(2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea; Tivozanib; KRN-951; 1-{2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea

Molecular FormulaC22H19ClN4O5

Molecular Weight454.86

Purity≥98 (HPLC)%

Density1.4±0.1 g/cm3

Boiling Point550.4±50.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9057338 Purity: ≥98 (HPLC)%
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Quality Control of [ 475108-18-0 ] Purity: ≥98 (HPLC)% SDS Specification MoL

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Chemical & Physical Properties
CAS Number475108-18-0
Catalog No.2A-9057338
Chinese Name替沃扎尼
SynonymsAV951; AV-951; N-(2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea; Tivozanib; KRN-951; 1-{2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea
Molecular FormulaC22H19ClN4O5
Molecular Weight454.86
Purity≥98 (HPLC)
Density1.4±0.1 g/cm3
Boiling Point550.4±50.0 °C at 760 mmHg
Appearancepowder
Storage Condition-20°C
ApplicationTivozanib (AV-951; KRN951) is a potent and selective VEGFR 1/2/3 inhibitor with IC50 values ​​of 0.21, 0.16, and 0.24 nM respectively.
MDL NumberMFCD15146788
SMILESO=C(NC1=C(Cl)C=C(C=C1)OC2=C3C=C(C(OC)=CC3=NC=C2)OC)NC4=NOC(C)=C4
InChI1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChI KeySPMVMDHWKHCIDT-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/57338_1_475108_18_0.pdf
Transport InfoProduct name: Tivozanib (AV-951)
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