CAS Number404950-80-7
SynonymsPanobinostat; (2E)-N-Hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide; (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Farydak; LBH589; (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide; (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE; (E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide; LBH-589; (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide
Molecular FormulaC21H23N3O2
Molecular Weight349.43
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Melting Point114-117?C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 404950-80-7 |
| Catalog No. | 2A-9057073 |
| Chinese Name | 帕比司他 |
| Synonyms | Panobinostat; (2E)-N-Hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide; (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Farydak; LBH589; (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide; (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE; (E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide; LBH-589; (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide |
| Molecular Formula | C21H23N3O2 |
| Molecular Weight | 349.43 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Melting Point | 114-117?C |
| Appearance | powder |
| Storage Condition | -20°C Freezer, Under Inert Atmosphere |
| Application | Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor. |
| HTC | 2933990090 |
| MDL Number | MFCD09833242 |
| SMILES | CC1=C(CCNCC2=CC=C(/C=C/C(NO)=O)C=C2)C3=CC=CC=C3N1 |
| InChI | 1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+ |
| InChI Key | FPOHNWQLNRZRFC-ZHACJKMWSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/57073_1_404950_80_7.pdf |
| Use of | Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor. Properties Name panobinostat Synonym More Synonyms Panobinostat (LBH589) Biological Activity Description Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Research Areas >> Cancer In Vitro Panobinosta (LBH589) induces apoptosis of both MOLT-4 and Reh cells in a time- and dose-dependent manner. Panobinosta treatment results in histone (H3K9 and H4K8) hyperacetylation and regulation of cell-cycle control genes in Reh cells[1]. Panobinostat exhibites potent antiproliferative activity in human NSCLC cell lines with the IC50 ranging from 5 to 100 nM[2]. References [1]. Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. [2]. Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31. [3]. Ocio EM, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803. Chemical & Physical Properties Molecular Formula C21H23N3O2 Exact Mass 349.179016 PSA 77.15000 Index of Refraction 1.683 InChIKey FPOHNWQLNRZRFC-ZHACJKMWSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route Total: 1 Page Panobinostat Ca... CAS#:441741-66-8 Panobinostat (L... CAS#:404950-80-7 (E)-3-(4-(((2-(... CAS#:960058-93-9 Panobinostat (L... CAS#:404950-80-7 Precursor & DownStream Precursor 1 CAS#:441741-66-8 Panobinostat Ca... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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