CAS Number364782-34-3
SynonymsCinacalcet HCl; 1-naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)-, hydrochloride; N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine,hydrochloride; N-[(1R)-1-naphtalén-1-yléthyl]-3-[3-(trifluorométhyl)phényl]propan-1-amine chlorhydrate; (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride; N-[(1R)-1-Naphthalen-1-ylethyl]-3-[3-(trifluormethyl)phenyl]propan-1-aminhydrochlorid; Cinacalcet hydrochloride; N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine hydrochloride (1:1); N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride; N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride (1:1); Mimpara,Sensipar
Molecular FormulaC22H23N1Cl1F3
Molecular Weight393.88
Purity98.00%
Boiling Point440.9ºCat760mmHg
Melting Point175-177ºC
AppearanceOff-white to yellowish-brown solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 364782-34-3 |
| Catalog No. | 2A-9056844 |
| Chinese Name | 盐酸西那卡塞 |
| Synonyms | Cinacalcet HCl; 1-naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)-, hydrochloride; N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine,hydrochloride; N-[(1R)-1-naphtalén-1-yléthyl]-3-[3-(trifluorométhyl)phényl]propan-1-amine chlorhydrate; (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride; N-[(1R)-1-Naphthalen-1-ylethyl]-3-[3-(trifluormethyl)phenyl]propan-1-aminhydrochlorid; Cinacalcet hydrochloride; N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine hydrochloride (1:1); N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride; N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride (1:1); Mimpara,Sensipar |
| Molecular Formula | C22H23N1Cl1F3 |
| Molecular Weight | 393.88 |
| Purity | 98.00 |
| Boiling Point | 440.9ºCat760mmHg |
| Melting Point | 175-177ºC |
| Appearance | Off-white to yellowish-brown solid |
| Storage Condition | -20°C Freezer |
| Application | Cinacalcet hydrochloride is an orally available Ca receptor (CaR) agonist used to treat cardiovascular disease. |
| HTC | 2921499090 |
| MDL Number | MFCD08067750 |
| SMILES | CC(NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12.Cl |
| InChI | InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1 |
| InChI Key | QANQWUQOEJZMLL-PKLMIRHRSA-N |
| MSDS | msds/56844_1_364782_34_3.pdf |
| Use of | Cinacalcet hydrochloride is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment. Properties Name cinacalcet hydrochloride Synonym More Synonyms Cinacalcet hydrochloride Biological Activity Description Cinacalcet hydrochloride is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment. Related Catalog Signaling Pathways >> GPCR/G Protein >> CaSR Research Areas >> Cardiovascular Disease References [1]. Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76. [2]. D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. Chemical & Physical Properties Exact Mass 393.147125 PSA 12.03000 LogP 7.33490 InChIKey QANQWUQOEJZMLL-PKLMIRHRSA-N Safety Information Hazard Codes C HS Code 2921499090 Synthetic Route (R)-(1-(naphtha... 1093944-40-1 Cinacalcet hydr... 364782-34-3 Literature: Dipharma Francis S.r.l. Patent: EP2022777 A2, 2009 ; Location in patent: Page/Page column 6 ; N-[(1R)-1-(naph... 1240705-66-1 Cinacalcet hydr... 364782-34-3 1273259-52-1 Cinacalcet hydr... 364782-34-3 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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