| Chemical & Physical Properties | |
|---|---|
| CAS Number | 289656-45-7 |
| Catalog No. | 2A-9056357 |
| Chinese Name | 4-氟-A-(4-氟苯基)-A-苯基-苯甲酰胺 |
| Synonyms | UNII-TS6G201A6Q; Senicapoc |
| Molecular Formula | C20H15F2NO |
| Molecular Weight | 323.34 |
| Purity | ≥98 (HPLC) |
| Density | 1.25g/cm3 |
| Boiling Point | 460.7ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | Senicapoc (ICA-17043) is a potent and selective blocker of Gardos channels with an IC50 of 11 nM. It blocks Ca2+-induced rubidium flux from human red blood cells with an IC50 of 11 nM and inhibits red |
| HTC | 2924299090 |
| MDL Number | MFCD09027349 |
| SMILES | O=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3 |
| InChI | 1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) |
| InChI Key | SCTZUZTYRMOMKT-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/56357_1_289656_45_7.pdf |
| Use of | Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM. Properties Name 2,2-bis(4-fluorophenyl)-2-phenylacetamide Synonym More Synonyms Senicapoc Biological Activity Description Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Others IC50: 11 nM (Gardos channel) References [1]. Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15;101(6):2412-8. [3]. Staal RG, et al. Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury. Eur J Pharmacol. 2017 Jan 15;795:1-7. Chemical & Physical Properties Molecular Formula C20H15F2NO Exact Mass 323.11200 PSA 43.09000 LogP 4.48480 Index of Refraction 1.594 Safety Information HS Code 2924299090 Synthetic Route 4,4′-difluorobe... CAS#:345-92-6 CAS#:289656-45-7 Literature: Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392 phenylmagnesium... CAS#:100-58-3 CAS#:289656-45-7 Literature: Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392 4,4′-difluorobe... CAS#:345-92-6 CAS#:289656-45-7 bis-(4-fluoro-p... CAS#:386-95-8 Literature: Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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