CAS Number225937-10-0
Synonyms(2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol monohydrate; EINECS 230-731-2; (2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol hydrate; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, hydrate (1:1); 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-, hydrate (1:1); MFCD00150865; D-CATECHOL HYDRATE; (+)-Cyanidol-3; D-CATECHIN HYDRATE; (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; D-CATECHIN; CYANIDOL HYDRATE; Catechin Hydrate; (+)-Cyanidol-3,(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; （＋）－Catechin Hydrate; (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol hydrate (1:1); 2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol hydrate (1:1); (+)-C; (2R,3S)-2-(3,4-Dihydroxy
Molecular FormulaC15H16O7
Molecular Weight308.29
Purity98.00%
Boiling Point630.4ºC at760mmHg
Melting Point175-177ºC
AppearanceSolid;White to Yellow to Orange powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 225937-10-0 |
| Catalog No. | 2A-9055832 |
| Chinese Name | (+)-儿茶素水合物 |
| Synonyms | (2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol monohydrate; EINECS 230-731-2; (2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol hydrate; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, hydrate (1:1); 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-, hydrate (1:1); MFCD00150865; D-CATECHOL HYDRATE; (+)-Cyanidol-3; D-CATECHIN HYDRATE; (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; D-CATECHIN; CYANIDOL HYDRATE; Catechin Hydrate; (+)-Cyanidol-3,(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; （＋）－Catechin Hydrate; (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol hydrate (1:1); 2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol hydrate (1:1); (+)-C; (2R,3S)-2-(3,4-Dihydroxy |
| Molecular Formula | C15H16O7 |
| Molecular Weight | 308.29 |
| Purity | 98.00 |
| Boiling Point | 630.4ºC at760mmHg |
| Melting Point | 175-177ºC |
| Appearance | Solid;White to Yellow to Orange powder to crystal |
| Water Solubility | Water solubility: slightly soluble; soluble in: ac |
| Storage Condition | 0-10°C; store in inert gas; avoid air, heat |
| Application | (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
| MDL Number | MFCD03547909 |
| Hazard Symbols | transportation |
| MSDS | msds/55832_1_225937_10_0.pdf |
| Bioactivity | (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Related Catalog Research Areas >> Cancer Natural Products >> Flavonoids Target COX-1:1.4 μM (IC50) In Vitro (+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM[1]. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells[2]. In Vivo Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)[3]. Cell Assay The Cell viability assay is performed to assess the toxicity of different concentrations of (+)-Catechin on MCF-7 cells. Briefly, MCF-7 cells (2×104 cells/well) are plated in 96-well plates and treated with 0 μg/mL (+)-Catechin and 160 μg/mL (+)-Catechin for 24 hours. Then, 40 μL of the Cell Titer Blue solution is directly added to the wells and incubated at 37°C for 6 hours. The fluorescence is recorded with a 560 nm/590 nm (excitation/emission) filter set using a microplate fluorescence reader, and the IC50 is calculated. Quadruplet samples are run for each concentration of (+)-Catechin in three independent experiments[2]. Animal Admin Rats[3] Twelve weeks old, healthy male rats weighing 200 to 230 g are used in this study. Rats are divided into four experimental groups (n=9 each) for one vehicle and three groups of (+)-Catechin (three doses). The doses of (+)-Catechin are prepared at 50, 100, 200 mg/kg and administered orally for 7 days prior to and during the experimental trials. Episodic memory, the conscious memory of the past experiences is evaluated in this study[3]. References [1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [2]. Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167. [3]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259. Chemical & Physical Properties Boiling Point 630.4ºC at760mmHg Melting Point 175-177ºC Molecular Formula C15H14O6.xH2O Molecular Weight 308.283 Flash Point 335ºC Exact Mass 308.089600 PSA 119.61000 LogP 1.48180 Vapour Pressure 9.29E-17mmHg at 25°C |
| Use of | (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Properties Articles16 Name (+)-catechin hydrate Synonym More Synonyms (+)-Catechin hydrate Biological Activity Description (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Related Catalog Research Areas >> Cancer Natural Products >> Flavonoids COX-1:1.4 μM (IC50) References [1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [3]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259. Chemical & Physical Properties Molecular Formula C15H14O6.xH2O Exact Mass 308.089600 PSA 119.61000 LogP 1.48180 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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