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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 131189-57-6 |
| Catalog No. | 2A-9052089 |
| Chinese Name | 山茱萸新苷 |
| Synonyms | Y0054; N1926; Cornuside |
| Molecular Formula | C24H30O14 |
| Molecular Weight | 542.49 |
| Purity | ≥90.0 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 817.6±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃, sealed, dry |
| Application | Cornuside is an iridoid glycoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., a traditional Oriental medicine used to treat inflammatory diseases and promote blood circulation. Cornu |
| MDL Number | MFCD21606970 |
| SMILES | O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@H]2OC=C([C@@H]([C@@H]2C=C)CCOC(=O)c3cc(c(c(c3)O)O)O)C(=O)OC |
| InChI | 1S/C24H30O14/c1-3-11-12(4-5-35-21(32)10-6-14(26)17(28)15(27)7-10)13(22(33)34-2)9-36-23(11)38-24-20(31)19(30)18(29)16(8-25)37-24/h3,6-7,9,11-12,16,18-20,23-31H,1,4-5,8H2,2H3/t11-,12+,16+,18+,19-,20+,23+,24-/m0/s1 |
| InChI Key | SMTKSCGLXONVGL-ZEIULZLQSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/52089_1_131189_57_6.pdf |
| Bioactivity | Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Target p38 MAP kinase NF-κB References [1]. Li L, et al. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Biochem Biophys Res Commun. 2016 Apr 29;473(2):408-14. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 817.6±65.0 °C at 760 mmHg Molecular Formula C24H30O14 Molecular Weight 542.487 Flash Point 274.5±27.8 °C Exact Mass 542.163574 PSA 221.90000 LogP -0.31 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.648 InChIKey SMTKSCGLXONVGL-ZEIULZLQSA-N SMILES C=CC1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CCOC(=O)c1cc(O)c(O)c(O)c1 |
| Use of | Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1]. Properties Articles10 Name methyl (2R,3S,4R)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate Synonym More Synonyms Cornuside Biological Activity Description Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology p38 MAP kinase References [1]. Li L, et al. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Biochem Biophys Res Commun. 2016 Apr 29;473(2):408-14. Chemical & Physical Properties Molecular Formula C24H30O14 Exact Mass 542.163574 PSA 221.90000 LogP -0.31 Index of Refraction 1.648 InChIKey SMTKSCGLXONVGL-ZEIULZLQSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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