CAS Number131179-95-8
Synonyms2-Dacmpp; Efaproxyn; 2-[4-((((3,5-dimethylphenyl)-amino)carbonyl)methyl)phenoxy]-2-methyl propionic acid; RSR13; 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid; Efaproxiral; 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid; Efaproxiral Sodium
Molecular FormulaC20H23O4N1
Molecular Weight341.41
Purity98.00%
Density1.202g/cm3
Boiling Point554.5ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 131179-95-8 |
| Catalog No. | 2A-9052087 |
| Chinese Name | 乙丙昔罗 |
| Synonyms | 2-Dacmpp; Efaproxyn; 2-[4-((((3,5-dimethylphenyl)-amino)carbonyl)methyl)phenoxy]-2-methyl propionic acid; RSR13; 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid; Efaproxiral; 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid; Efaproxiral Sodium |
| Molecular Formula | C20H23O4N1 |
| Molecular Weight | 341.41 |
| Purity | 98.00 |
| Density | 1.202g/cm3 |
| Boiling Point | 554.5ºC at 760mmHg |
| Storage Condition | 2-8℃ |
| Application | Efaproxiral is an allosteric modulator of hemoglobin (Hb) synthesis that reduces the oxygen (O2) binding affinity of hemoglobin. |
| HTC | 2924299090 |
| MDL Number | MFCD00899086 |
| SMILES | Cc1cc(C)cc(NC(=O)Cc2ccc(OC(C)(C)C(=O)O)cc2)c1 |
| InChI | InChI=1S/C20H23NO4/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24) |
| InChI Key | BNFRJXLZYUTIII-UHFFFAOYSA-N |
| MSDS | msds/52087_1_131179_95_8.pdf |
| Use of | Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT. Properties Name 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid Synonym More Synonyms Efaproxiral Biological Activity Description Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer References [1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784. Chemical & Physical Properties Molecular Formula C20H23NO4 Exact Mass 341.16300 PSA 75.63000 LogP 3.79960 Index of Refraction 1.597 InChIKey BNFRJXLZYUTIII-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2924299090 Synthetic Route tert-butyl 2-(4... CAS#:1019680-83-1 Efaproxiral CAS#:131179-95-8 Literature: Chemical Communications, , # 9 p. 1100 - 1102 2-Bromo-2-methy... CAS#:2052-01-9 N-(3,5-dimethyl... CAS#:131179-77-6 Efaproxiral CAS#:131179-95-8 Literature: Synthetic Communications, , vol. 36, # 15 p. 2129 - 2133 Chloroform CAS#:67-66-3 N-(3,5-dimethyl... CAS#:131179-77-6 CAS#:67-64-1 Efaproxiral CAS#:131179-95-8 Literature: Journal of Medicinal Chemistry, , vol. 34, # 2 p. 752 - 757 Precursor & DownStream Precursor 7 CAS#:2052-01-9 2-Bromo-2-methy... CAS#:131179-77-6 N-(3,5-dimethyl... CAS#:67-66-3 Chloroform CAS#:67-64-1 DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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