CAS Number25952-53-8
SynonymsN-(3-(Dimethylamino)propyl)-N'-ethylcarbodiimide hydrochloride; 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride; Carbodiimide, (3-dimethylaminopropyl)ethyl-, monohydrochloride; EDC HCL; EDAC,Hydrochloride; N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride; Carbodiimide, [3-(dimethylamino)propyl]ethyl-, hydrochloride; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide monohydrochloride; 1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride; N'-(Ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine hydrochlo
Molecular FormulaC8H18ClN3
Molecular Weight191.70
Purity98.5%
Density0.877 g/mL at 20 °C(lit.)
Boiling Point269.1ºC at 760 mmHg
Melting Point110-115 °C(lit.)
Appearancepowder
EINECS247-361-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25952-53-8 |
| Catalog No. | 2A-9000516 |
| Chinese Name | 1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐 |
| Synonyms | N-(3-(Dimethylamino)propyl)-N'-ethylcarbodiimide hydrochloride; 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride; Carbodiimide, (3-dimethylaminopropyl)ethyl-, monohydrochloride; EDC HCL; EDAC,Hydrochloride; N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride; Carbodiimide, [3-(dimethylamino)propyl]ethyl-, hydrochloride; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide monohydrochloride; 1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride; N'-(Ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine hydrochlo |
| Molecular Formula | C8H18ClN3 |
| Molecular Weight | 191.70 |
| Purity | 98.5 |
| Density | 0.877 g/mL at 20 °C(lit.) |
| Boiling Point | 269.1ºC at 760 mmHg |
| Melting Point | 110-115 °C(lit.) |
| Appearance | powder |
| Water Solubility | Soluble |
| Storage Condition | −20°C |
| Application | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acids and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochl |
| EINECS | 247-361-2 |
| HTC | 29252000 |
| PubChem ID | 24894654 |
| MDL Number | MFCD00012503 |
| SMILES | [Cl-].CCN(CCC[NH+](C)C)C#N |
| InChI | InChI=1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H |
| InChI Key | InChIKey=FDXPUDRRFDHONO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 5764110 |
| NACRES Code | NA.31 |
| UNSPSC | 12352111 |
| Hazard Symbols | Transport |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S37/39 |
| MSDS | msds/516_1_25952_53_8.pdf |
| Bioactivity | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl) is a very useful agent to form amide bonds (peptide bonds) in an aqueous medium[1]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl), is widely used for polyaniline-carbon nanotube preparation for a cholesterol biosensor, precolumn derivatization of aliphatic amines for HPLC, molecular beacons formation for DNA reseach, sensor preparation for calcium detection, the fluorescent determination of carboxylic acids, and solidphase microsequencing of peptides[2]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl) is an aminoaldehyde dehydrogenase (AMADH) inhibitor, while its inhibition on glutamate decarboxylase (GAD) is insignificant[3]. References [1]. Kunihiko Seno, et al. Spectrophotometric determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow injection analysis. Anal Sci. 2008 Apr;24(4):505-8. [2]. Kunihiko Seno, et al. Determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow-injection analysis based on a specific condensation reaction between malonic acid and ethylenediamine. Anal Sci. 2009 Mar;25(3):389-93. [3]. Runqiang Yang, et al. AMADH inhibitor optimization and its effects on GABA accumulation in soybean sprouts under NaCl-CaCl 2 treatment. 3 Biotech. 2019 May;9(5):184. Chemical & Physical Properties Density 0.877 g/mL at 20 °C(lit.) Boiling Point 269.1ºC at 760 mmHg Melting Point 110-115 °C(lit.) Molecular Formula C8H18ClN3 Molecular Weight 191.70 Flash Point 107.9ºC Exact Mass 191.118927 PSA 27.96000 LogP 1.93390 Vapour Pressure 0.171mmHg at 25°C Index of Refraction n20/D 1.461 Storage condition −20°C Stability Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture. Water Solubility Soluble |
| Use of | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2]. Properties Articles104 Name 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine,hydrochloride Synonym More Synonyms Biological Activity Description 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl) is a very useful agent to form amide bonds (peptide bonds) in an aqueous medium[1]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl), is widely used for polyaniline-carbon nanotube preparation for a cholesterol biosensor, precolumn derivatization of aliphatic amines for HPLC, molecular beacons formation for DNA reseach, sensor preparation for calcium detection, the fluorescent determination of carboxylic acids, and solidphase microsequencing of peptides[2]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl) is an aminoaldehyde dehydrogenase (AMADH) inhibitor, while its inhibition on glutamate decarboxylase (GAD) is insignificant[3]. References [1]. Kunihiko Seno, et al. Spectrophotometric determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow injection analysis. Anal Sci. 2008 Apr;24(4):505-8. [2]. Kunihiko Seno, et al. Determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow-injection analysis based on a specific condensation reaction between malonic acid and ethylenediamine. Anal Sci. 2009 Mar;25(3):389-93. [3]. Runqiang Yang, et al. AMADH inhibitor optimization and its effects on GABA accumulation in soybean sprouts under NaCl-CaCl 2 treatment. 3 Biotech. 2019 May;9(5):184. Chemical & Physical Properties Exact Mass 191.118927 PSA 27.96000 LogP 1.93390 Stability Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture. Water Solubility Soluble |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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