CAS Number117772-70-0
Synonyms1-Oxa-6-azacyclopentadecan-15-one; N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A CP-62993; Azithromycindihydrate; Azithromycin Dihydrate; Azithromycin (hydrate)
Molecular FormulaC38H76N2O14
Molecular Weight785.02
Purity98.00%
Density1.18g/cm3
Boiling Point822.1ºC at 760mmHg
Melting Point113-115ºC
AppearanceWhite or almost white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 117772-70-0 |
| Catalog No. | 2A-9051130 |
| Chinese Name | 阿奇霉素二水合物 |
| Synonyms | 1-Oxa-6-azacyclopentadecan-15-one; N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A CP-62993; Azithromycindihydrate; Azithromycin Dihydrate; Azithromycin (hydrate) |
| Molecular Formula | C38H76N2O14 |
| Molecular Weight | 785.02 |
| Purity | 98.00 |
| Density | 1.18g/cm3 |
| Boiling Point | 822.1ºC at 760mmHg |
| Melting Point | 113-115ºC |
| Appearance | White or almost white crystalline powder |
| Storage Condition | Room temperature, dry, sealed |
| Application | Azithromycin hydrate is a macrolide antibiotic commonly used to treat bacterial infections. |
| HTC | 29419000 |
| PubChem ID | 329823110 |
| MDL Number | MFCD01862248 |
| SMILES | O.O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O |
| InChI | 1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1 |
| InChI Key | SRMPHJKQVUDLQE-KUJJYQHYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/51130_1_117772_70_0.pdf |
| Bioactivity | Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells[1]. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells[2]. In Vivo Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice[1]. Cell Assay THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. References [1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. Chemical & Physical Properties Density 1.18g/cm3 Boiling Point 822.1ºC at 760mmHg Melting Point 113-115ºC Molecular Formula C38H76N2O14 Molecular Weight 785.015 Flash Point 451ºC Exact Mass 784.529663 PSA 198.54000 LogP 1.71000 Vapour Pressure 2.51E-31mmHg at 25°C InChIKey SRMPHJKQVUDLQE-RBYSYZSCSA-N SMILES CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O.O.O |
| Use of | Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Properties Articles127 Name azithromycin dihydrate Synonym More Synonyms Azithromycin Dihydrate Biological Activity Description Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. Chemical & Physical Properties Molecular Formula C38H76N2O14 Exact Mass 784.529663 PSA 198.54000 LogP 1.71000 InChIKey SRMPHJKQVUDLQE-RBYSYZSCSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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