CAS Number113963-68-1
SynonymsRo 31-6045; 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide; MFCD00236433; 3,4-Di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione; bisindolylmaleimide v; 3,4-bis(3-indolyl)-1-methyl-pyrrole-2,5-dione; 1-Methyl-3,4-bis(3-indolyl)maleimide; 1H-Pyrrole-2,5-dione,3,4-di-1H-indol-3-yl-1-methyl; n-methylbis(indol-3-yl)maleimide
Molecular FormulaC21H15N3O2
Molecular Weight341.363
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point655.7±55.0 °C at 760 mmHg
Melting Point271°C
Appearancered solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 113963-68-1 |
| Catalog No. | 2A-9050794 |
| Chinese Name | 双吲哚马来酰亚胺V |
| Synonyms | Ro 31-6045; 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide; MFCD00236433; 3,4-Di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione; bisindolylmaleimide v; 3,4-bis(3-indolyl)-1-methyl-pyrrole-2,5-dione; 1-Methyl-3,4-bis(3-indolyl)maleimide; 1H-Pyrrole-2,5-dione,3,4-di-1H-indol-3-yl-1-methyl; n-methylbis(indol-3-yl)maleimide |
| Molecular Formula | C21H15N3O2 |
| Molecular Weight | 341.363 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 655.7±55.0 °C at 760 mmHg |
| Melting Point | 271°C |
| Appearance | red solid |
| Water Solubility | DMSO: soluble |
| Storage Condition | Stable under normal temperature and pressure, avoi |
| Application | Bisindolylcarboximide V is a cell-permeable negative control used in protein kinase C inhibition studies with an IC50 value exceeding 100µM [1]. Bisindolylcarboximide V blocks the activation of mitoge |
| HTC | 2933990090 |
| SMILES | CN1C(=O)C(c2c[nH]c3ccccc23)=C(c2c[nH]c3ccccc23)C1=O |
| InChI | InChI=1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3 |
| InChI Key | SWAWYMIKGOHZMR-UHFFFAOYSA-N |
| Bioactivity | Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) References [1]. Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4. [2]. Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 655.7±55.0 °C at 760 mmHg Melting Point 271°C Molecular Formula C21H15N3O2 Molecular Weight 341.363 Flash Point 350.3±31.5 °C Exact Mass 341.116425 PSA 68.96000 LogP 3.65 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.794 InChIKey SWAWYMIKGOHZMR-UHFFFAOYSA-N SMILES CN1C(=O)C(c2c[nH]c3ccccc23)=C(c2c[nH]c3ccccc23)C1=O Storage condition −20°C Water Solubility DMSO: soluble |
| Use of | Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2]. Properties Name 3,4-bis(1H-indol-3-yl)-1-methylpyrrole-2,5-dione Synonym More Synonyms n-methylbis(indol-3-yl)maleimide Biological Activity Description Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) References [1]. Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4. [2]. Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40. Chemical & Physical Properties Molecular Formula C21H15N3O2 Exact Mass 341.116425 PSA 68.96000 Index of Refraction 1.794 InChIKey SWAWYMIKGOHZMR-UHFFFAOYSA-N Water Solubility DMSO: soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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