CAS Number112901-68-5
SynonymsS-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate trihydrate; MFCD00233058; UNII-M487QF2F4V; WR-2721; Anifostine trihydrate; Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester), hydrate (1:3); Amifostine; Amifostine trihydrate
Molecular FormulaC5H21N2O6PS
Molecular Weight268.27
Purity98.00%
Density1.367g/cm3
Boiling Point441.7ºC at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 112901-68-5 |
| Catalog No. | 2A-9050717 |
| Chinese Name | 氨磷汀 |
| Synonyms | S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate trihydrate; MFCD00233058; UNII-M487QF2F4V; WR-2721; Anifostine trihydrate; Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester), hydrate (1:3); Amifostine; Amifostine trihydrate |
| Molecular Formula | C5H21N2O6PS |
| Molecular Weight | 268.27 |
| Purity | 98.00 |
| Density | 1.367g/cm3 |
| Boiling Point | 441.7ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective and radioprotective agent. Amifostine trihydrate selectively protects normal tissue from damage caused by radiation and che |
| HTC | 2930909090 |
| PubChem ID | 329748972 |
| MDL Number | MFCD00453866 |
| SMILES | OP(SCCNCCCN)(O)=O.O.O.O |
| InChI | 1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2 |
| InChI Key | TXQPXJKRNHJWAX-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/50717_1_112901_68_5.pdf |
| Bioactivity | Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase References [1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [3]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40. [4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37. [5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14. Chemical & Physical Properties Density 1.367g/cm3 Boiling Point 441.7ºC at 760 mmHg Molecular Formula C5H21N2O6PS Molecular Weight 268.269 Flash Point 220.9ºC Exact Mass 268.085785 PSA 158.38000 LogP 0.64900 Appearance of Characters powder Vapour Pressure 4.9E-09mmHg at 25°C InChIKey TXQPXJKRNHJWAX-UHFFFAOYSA-N SMILES NCCCNCCSP(=O)(O)O.O.O.O Storage condition 2-8°C |
| Use of | Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4]. Properties Articles30 Name 2-(3-aminopropylamino)ethylsulfanylphosphonic acid,trihydrate Synonym More Synonyms Amifostine trihydrate Biological Activity Description Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase References [1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37. [5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14. Chemical & Physical Properties Molecular Formula C5H21N2O6PS Exact Mass 268.085785 PSA 158.38000 LogP 0.64900 Appearance of Characters powder InChIKey TXQPXJKRNHJWAX-UHFFFAOYSA-N SMILES NCCCNCCSP(=O)(O)O.O.O.O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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